The MG-QOL15 Japanese version: Validation and associations with clinical factors

Masayuki Masuda, Kimiaki Utsugisawa, Shigeaki Suzuki, Yuriko Nagane, Suguru Ito, Chiaki Kabasawa, Yasushi Suzuki, Yuko Shimizu, Hiroya Utsumi, Kazuo Fujihara, Shinichiro Uchiyama, Norihiro Suzuki

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We produced a Japanese translation of the 15-item myasthenia gravis (MG)-specific quality of life (QOL) scale (MG-QOL15), assessed its reliability and validity, and examined clinical factors affecting the self-perceived QOL in MG. Consecutive 327 patients with MG seen at six neurological centers were evaluated. All patients completed an MG-QOL15 Japanese version (MG-QOL15-J), the Beck Depression Inventory-Second Edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the MG Foundation of America (MGFA) quantitative MG score and the MG composite. The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA postintervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.

Original languageEnglish
Pages (from-to)1043-1046
Number of pages4
JournalClinical Neurology
Issue number11
Publication statusPublished - 2012


  • Cross-sectional study
  • Health-related quality of life
  • Myasthenia gravis
  • Questionnaire
  • Validity

ASJC Scopus subject areas

  • Clinical Neurology


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