The molecular logic of pemphigus and impetigo: The desmoglein story

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Desmosomes are intercellular adhesive junctions of epithelial cells that contain two major transmembrane components, desmogleins (Dsg) and desmocollins; these are both cadherin-type cell-cell adhesion molecules. Pemphigus is an autoimmune blistering disease caused by IgG autoantibodies that target Dsg1 and Dsg3 in pemphigus foliaceus and pemphigus vulgaris respectively. Bullous impetigo is a common and highly contagious superficial skin infection caused by Staphylococcus aureus. Staphylococcal scalded skin syndrome (SSSS) is a generalized form of bullous impetigo. The blisters in bullous impetigo and SSSS are induced by exfoliative toxin that specifically cleaves Dsg1. Clinical and microscopic localization of blisters in pemphigus, bullous impetigo and SSSS are logically explained at the molecular level by the desmoglein compensation theory; the similarity of lesions among these diseases is underscored by a similar pathogenesis.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalVeterinary Dermatology
Volume20
Issue number5-6
DOIs
Publication statusPublished - 2009 Oct

Fingerprint

Desmogleins
pemphigus (skin disease)
Impetigo
Staphylococcal Scalded Skin Syndrome
Pemphigus
blisters
Blister
Desmocollins
Exfoliatins
desmosomes
Desmosomes
autoantibodies
Intercellular Junctions
cadherins
Cell Adhesion Molecules
Cadherins
cell adhesion
adhesives
Adhesives
Autoantibodies

ASJC Scopus subject areas

  • veterinary(all)

Cite this

The molecular logic of pemphigus and impetigo : The desmoglein story. / Amagai, Masayuki.

In: Veterinary Dermatology, Vol. 20, No. 5-6, 10.2009, p. 308-312.

Research output: Contribution to journalArticle

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