The Musashi family RNA-binding proteins in stem cells

Kenichi Horisawa, Takao Imai, Hideyuki Okano, Hiroshi Yanagawa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The Musashi family is an evolutionarily conserved group of RNA-binding proteins. In mammal, two members of the group, Msi1 and Msi2, have been identified to date. Msi1 is considered to play roles in maintaining the stem cell status (stemness) of neural stem/progenitor cells in adults and in the development of central nervous system through translational regulation of its target mRNAs, which encode regulators of signal transduction and the cell cycle. Recently, strong expression of Msi1 in various somatic stem/progenitor cells of adult tissues, such as eye, gut, stomach, breast, and hair follicle, has been reported. The protein is also expressed in various cancer cells, and ectopically emerging cells have been found in neural tissues of patients with diseases involving neural disorder, including epilepsy. Many novel target mRNAs and regulatory pathways of Msi1 have been reported in recent years. Here, we present a review of the functions and action mechanisms of Msi1 protein and discuss possible directions for further study.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalBiomolecular Concepts
Volume1
Issue number1
DOIs
Publication statusPublished - 2010 May 1

Fingerprint

RNA-Binding Proteins
Stem cells
Stem Cells
Cells
Tissue
Signal transduction
Messenger RNA
Adult Stem Cells
Mammals
Neural Stem Cells
Hair Follicle
Neurology
Epilepsy
Signal Transduction
Stomach
Cell Cycle
Proteins
Breast
Central Nervous System
Neoplasms

Keywords

  • Musashi
  • post-transcriptional regulation
  • progenitor cell
  • RNA-binding protein
  • stem cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cellular and Molecular Neuroscience

Cite this

The Musashi family RNA-binding proteins in stem cells. / Horisawa, Kenichi; Imai, Takao; Okano, Hideyuki; Yanagawa, Hiroshi.

In: Biomolecular Concepts, Vol. 1, No. 1, 01.05.2010, p. 59-66.

Research output: Contribution to journalArticle

Horisawa, Kenichi ; Imai, Takao ; Okano, Hideyuki ; Yanagawa, Hiroshi. / The Musashi family RNA-binding proteins in stem cells. In: Biomolecular Concepts. 2010 ; Vol. 1, No. 1. pp. 59-66.
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