The new pemphigus variants

N. D. Robinson, T. Hashimoto, M. Amagai, L. S. Chan

Research output: Contribution to journalArticlepeer-review

219 Citations (Scopus)


Pemphigus describes a group of autoimmune diseases characterized by blisters and erosions of the skin and mucous membranes, acantholysis by histology, and autoantibodies directed against epidermal cell surface components. Since the early 1970s, the following new clinical variants of pemphigus have been reported: pemphigus herpetiformis, IgA pemphigus, and paraneoplastic pemphigus. In recent years, significant data have been obtained from laboratory investigation on these rare and atypical variants, especially regarding their specific target antigens. We review these variants, their clinical presentations, histologic findings, immunopathology, target antigens, theories of pathogenesis, treatment modalities, and clinical courses.

Original languageEnglish
Pages (from-to)649-671
Number of pages23
JournalJournal of the American Academy of Dermatology
Issue number5 I
Publication statusPublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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