The Ocular Surface Glycocalyx and its Alteration in Dry Eye Disease

A Review

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Many studies have revealed that transmembrane mucins, large glycoproteins with heavily glycosylated glycans, are essential for maintaining ocular surface epithelium lubrication and wettability. Recent reports indicate that transmembrane mucins and galectin-3, a chimera type of galectin that binds β-galactoside in the glycan, play a crucial role in maintaining the epithelial glycocalyx barrier. This review summarizes current evidence regarding the role of galectin-3, the role of the three major transmembrane mucins (i.e., MUC1, MUC4, and MUC16), in the maintenance of ocular surface wettability and transcellular barrier. Pathological mechanisms of glycocalyx barrier disruption and epithelial surface wettability decreases in dry eye disease are also summarized. Lastly, new ophthalmic drugs that target transmembrane mucin are described.

Original languageEnglish
Pages (from-to)DES157-DES162
JournalInvestigative ophthalmology & visual science
Volume59
Issue number14
DOIs
Publication statusPublished - 2018 Nov 1

Fingerprint

Wettability
Glycocalyx
Eye Diseases
Mucins
Galectin 3
Polysaccharides
Mucin-3
Galectins
Lubrication
Galactosides
Glycoproteins
Epithelium
Maintenance
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

The Ocular Surface Glycocalyx and its Alteration in Dry Eye Disease : A Review. / Uchino, Yuichi.

In: Investigative ophthalmology & visual science, Vol. 59, No. 14, 01.11.2018, p. DES157-DES162.

Research output: Contribution to journalArticle

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