The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Mayu Morita; Seiji Asoda; Kazuyuki Tsunoda; Tomoya Soma; Taneaki Nakagawa; Masayori Shirakawa; Hirofumi Shoji; Hisao Yagishita; Takeji Nishikawa; Hiromasa Kawana

doi:10.1007/s10266-016-0255-4

The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Mayu Morita, Seiji Asoda, Kazuyuki Tsunoda, Tomoya Soma, Taneaki Nakagawa, Masayori Shirakawa, Hirofumi Shoji, Hisao Yagishita, Takeji Nishikawa, Hiromasa Kawana

Department of Dentistry and Oral Surgery

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

Original language	English
Pages (from-to)	262-266
Number of pages	5
Journal	Odontology
Volume	105
Issue number	2
DOIs	https://doi.org/10.1007/s10266-016-0255-4
Publication status	Published - 2017 Apr 1

Keywords

Lip
Oral lichen planus
Squamous cell carcinoma
Tacrolimus

ASJC Scopus subject areas

Dentistry(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10266-016-0255-4

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title = "The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report",

abstract = "Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.",

keywords = "Lip, Oral lichen planus, Squamous cell carcinoma, Tacrolimus",

author = "Mayu Morita and Seiji Asoda and Kazuyuki Tsunoda and Tomoya Soma and Taneaki Nakagawa and Masayori Shirakawa and Hirofumi Shoji and Hisao Yagishita and Takeji Nishikawa and Hiromasa Kawana",

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doi = "10.1007/s10266-016-0255-4",

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T2 - a case report

AU - Morita, Mayu

AU - Asoda, Seiji

AU - Tsunoda, Kazuyuki

AU - Soma, Tomoya

AU - Nakagawa, Taneaki

AU - Shirakawa, Masayori

AU - Shoji, Hirofumi

AU - Yagishita, Hisao

AU - Nishikawa, Takeji

AU - Kawana, Hiromasa

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

AB - Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

KW - Lip

KW - Oral lichen planus

KW - Squamous cell carcinoma

KW - Tacrolimus

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JO - Odontology / the Society of the Nippon Dental University

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The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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