The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Mayu Morita, Seiji Asoda, Kazuyuki Tsunoda, Tomoya Soma, Taneaki Nakagawa, Masayori Shirakawa, Hirofumi Shoji, Hisao Yagishita, Takeji Nishikawa, Hiromasa Kawana

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6 Citations (Scopus)


Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalOdontology / the Society of the Nippon Dental University
Publication statusAccepted/In press - 2016 Jul 1



  • Lip
  • Oral lichen planus
  • Squamous cell carcinoma
  • Tacrolimus

ASJC Scopus subject areas

  • Dentistry(all)

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