TY - JOUR
T1 - The P300 event-related potential in bipolar disorder
T2 - A systematic review and meta-analysis
AU - Wada, Masataka
AU - Kurose, Shin
AU - Miyazaki, Takahiro
AU - Nakajima, Shinichiro
AU - Masuda, Fumi
AU - Mimura, Yu
AU - Nishida, Hana
AU - Ogyu, Kamiyu
AU - Tsugawa, Sakiko
AU - Mashima, Yuuki
AU - Plitman, Eric
AU - Chakravarty, M. Mallar
AU - Mimura, Masaru
AU - Noda, Yoshihiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Young Scientists (KAKENHI) (20807226), Research Grant from Japan Agency for Medical Research and development (AMED) ( 20807226 ) to YN. SN has received fellowship grants from CIHR , research support from Japan Society for the Promotion of Science , AMED , Japan Research Foundation for Clinical Pharmacology , Naito Foundation , Takeda Science Foundation , Uehara Memorial Foundation , and Daiichi Sankyo Scholarship Donation Program within the past three years. EP receives funding from the Healthy Brains for Healthy Lives Postdoctoral Fellowship. MM has received research support from the Japan Society for the Promotion of Science within the past three years. The funding agency did not contribute to the study design; in the data collection, analyses, and interpretation; in the writing of the manuscript; and in the decision to submit the manuscript for publication. YN receives an investigator-initiated clinical study grant from TEIJIN PHARMA LIMITED . He also receives research grants from Japan Health Foundation , Meiji Yasuda Mental Health Foundation , Mitsui Life Social Welfare Foundation , Takeda Science Foundation , SENSHIN Medical Research Foundation , Health Science Center Foundation , Mochida Memorial Foundation for Medical and Pharmaceutical Research , and Daiichi Sankyo Scholarship Donation Program . He receives equipment-in-kind support for an investigator-initiated study from Magventure Inc .
Publisher Copyright:
© 2019
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Background: Neurophysiology including P300, that is a typical index of event-related potential, may be potential biomarkers for bipolar disorder (BD) and it can be useful towards elucidating the pathophysiology of BD. However, previous findings from P300 studies were inconsistent due to the heterogeneity of research methods, which make it difficult to understand the neurobiological significance of them. The aim of this study is to conduct a meta-analysis on P300 in patients with BD. Method: A literature search was conducted using PubMed to identify studies that compared P300 event-related potential between patients with BD and healthy controls (HCs). We analyzed P300 indices such as amplitude and latency of P3a and P3b in auditory or visual paradigms. Further, moderator analyses were conducted to investigate the influence of patient characteristics (i.e. history of psychosis, diagnostic subcategories [BD-I/BD-II], and phase of illness [euthymic, manic, or depressive]) on P300 indices. Result: Out of 124 initial records, we included 30 articles (BD: N = 1331; HCs: N = 1818). Patients with BD showed reduced P3a and P3b amplitude in both paradigms and delayed P3b latency in auditory paradigms compared to HCs. There was no influence on the history of psychosis, diagnostic subcategories, or phase of illness on P300 indices. Limitation: The difference in medication use was difficult to control and it may affect the results. Conclusion: This meta-analysis provides evidence for P300 abnormalities in patients with BD compared to HCs. Our results suggest that P300 may be trait markers rather than state markers in this illness.
AB - Background: Neurophysiology including P300, that is a typical index of event-related potential, may be potential biomarkers for bipolar disorder (BD) and it can be useful towards elucidating the pathophysiology of BD. However, previous findings from P300 studies were inconsistent due to the heterogeneity of research methods, which make it difficult to understand the neurobiological significance of them. The aim of this study is to conduct a meta-analysis on P300 in patients with BD. Method: A literature search was conducted using PubMed to identify studies that compared P300 event-related potential between patients with BD and healthy controls (HCs). We analyzed P300 indices such as amplitude and latency of P3a and P3b in auditory or visual paradigms. Further, moderator analyses were conducted to investigate the influence of patient characteristics (i.e. history of psychosis, diagnostic subcategories [BD-I/BD-II], and phase of illness [euthymic, manic, or depressive]) on P300 indices. Result: Out of 124 initial records, we included 30 articles (BD: N = 1331; HCs: N = 1818). Patients with BD showed reduced P3a and P3b amplitude in both paradigms and delayed P3b latency in auditory paradigms compared to HCs. There was no influence on the history of psychosis, diagnostic subcategories, or phase of illness on P300 indices. Limitation: The difference in medication use was difficult to control and it may affect the results. Conclusion: This meta-analysis provides evidence for P300 abnormalities in patients with BD compared to HCs. Our results suggest that P300 may be trait markers rather than state markers in this illness.
KW - Biological markers
KW - Bipolar disorder
KW - Cognition
KW - EEG/Event-related potentials
KW - Electrophysiology
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U2 - 10.1016/j.jad.2019.06.010
DO - 10.1016/j.jad.2019.06.010
M3 - Review article
C2 - 31200163
AN - SCOPUS:85067303857
SN - 0165-0327
VL - 256
SP - 234
EP - 249
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -
