The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects

K. Nakao, A. Sugawara, N. Morii, M. Sakamoto, T. Yamada, Hiroshi Itoh, S. Shiono, Y. Saito, K. Nishimura, T. Ban, K. Kangawa, H. Matsuo, H. Imura

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Abstract

We have analysed the pharmacokinetics of α-human atrial natriuretic polypeptide (α-hANP) in healthy subjects, using a two-compartment open model following bolus intravenous injection. The plasma half-times for the fast and slow components were 1.7±0.07 min and 13.3±1.69 min respectively. V1 (the volume of the central compartment), Vz (volume of distribution) and Vss (volume of distribution at steady-state) were 5370±855 ml (89.5±14.3 ml·kg-1), 32000±4620 ml (533±77.0 ml·kg-1), and 11900±1530 ml (198±25.5 ml·kg-1) respectively. The mean plasma clearance was 1520±121 ml·min-1 (25.4±2.0 ml·min-1·kg-1.

Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume31
Issue number1
DOIs
Publication statusPublished - 1986 Jan
Externally publishedYes

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Healthy Volunteers
Pharmacokinetics
Peptides
Intravenous Injections

Keywords

  • α-hANP
  • atrial natriuretic polypeptide
  • pharmacokinetics
  • radioimmunassay

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology (medical)

Cite this

The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects. / Nakao, K.; Sugawara, A.; Morii, N.; Sakamoto, M.; Yamada, T.; Itoh, Hiroshi; Shiono, S.; Saito, Y.; Nishimura, K.; Ban, T.; Kangawa, K.; Matsuo, H.; Imura, H.

In: European Journal of Clinical Pharmacology, Vol. 31, No. 1, 01.1986, p. 101-103.

Research output: Contribution to journalArticle

Nakao, K, Sugawara, A, Morii, N, Sakamoto, M, Yamada, T, Itoh, H, Shiono, S, Saito, Y, Nishimura, K, Ban, T, Kangawa, K, Matsuo, H & Imura, H 1986, 'The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects', European Journal of Clinical Pharmacology, vol. 31, no. 1, pp. 101-103. https://doi.org/10.1007/BF00870995
Nakao, K. ; Sugawara, A. ; Morii, N. ; Sakamoto, M. ; Yamada, T. ; Itoh, Hiroshi ; Shiono, S. ; Saito, Y. ; Nishimura, K. ; Ban, T. ; Kangawa, K. ; Matsuo, H. ; Imura, H. / The pharmacokinetics of α-human atrial natriuretic polypeptide in healthy subjects. In: European Journal of Clinical Pharmacology. 1986 ; Vol. 31, No. 1. pp. 101-103.
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