The possible contribution of angiitis to the onset of benign paroxysmal positional vertigo (BPPV)

Fumiyuki Goto, Ken Hayashi, Takanobu Kunihiro, Kaoru Ogawa

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The aim was to evaluate the oxidative stress and the angiitis in patients with BPPV. Method: Patients with benign paroxysmal positional vertigo (BPPV) within 14 days of onset were analyzed. The level of diacron reactive oxygen metabolites (d-ROM) and circulating soluble vascular cell adhesion molecule 1 (VCAM-1), were evaluated. As a treatment the patients were taught to perform the Brandt-Daroff exercise at home by themselves. The prognosis of BPPV, which is measured as the time until the disappearance of positional nystagmus by a physician during the outpatient visit each week, the relation among the level of oxygen metabolites, vascular molecule and the duration until remission were analyzed. Results: The patients who required longer time for the disappearance of positional nystagmus showed high d-ROM and VCAM levels, whereas those who required shorter time for remission showed lower d-ROM and VCAM levels. Conclusion: There is an increased expression of VCAM-1 and d-ROM confirming the existence of an angiitis and supporting the vascular involvement in BPPV. The identification of the high levels of d-ROM and VCAM-1 can open the way to selective pharmacological treatments able to correct the oxidative stress and activation of endothelial cells.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalInternational Tinnitus Journal
Volume16
Issue number1
Publication statusPublished - 2010

Fingerprint

Vasculitis
Oxygen
Vascular Cell Adhesion Molecule-1
Physiologic Nystagmus
Blood Vessels
Oxidative Stress
Benign Paroxysmal Positional Vertigo
Outpatients
Endothelial Cells
Pharmacology
Exercise
Physicians
Therapeutics

Keywords

  • Diacron reactive oxygen metabolites
  • VCAM-1
  • Vertigo

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Speech and Hearing
  • Sensory Systems

Cite this

The possible contribution of angiitis to the onset of benign paroxysmal positional vertigo (BPPV). / Goto, Fumiyuki; Hayashi, Ken; Kunihiro, Takanobu; Ogawa, Kaoru.

In: International Tinnitus Journal, Vol. 16, No. 1, 2010, p. 25-28.

Research output: Contribution to journalArticle

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