The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors

Takashi Ando, Hirotaka Shibata, Toshihiko Suzuki, Isao Kurihara, Kouichi Hayashi, Matsuhiko Hayashi, Ikuo Saito, Hiroshi Kawabe, Minako Tsujioka, Takao Saruta

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11 Citations (Scopus)

Abstract

The expression levels of bcl-2, mcl-1/EAT, and bax were examined by Northern blot analysis and semi-quantitative RT-PCR method in 25 adrenal tumors, including seven adrenal pheochromocytomas (PHE), seven aldosterone- producing adenomas (APA), four adrenal cortisol-producing adenomas (CS), one deoxycorticosterone-producing adenoma (DOC) and six non-hyperfunctioning adrenal cortical adenomas (NF). Northern blot analysis revealed both bcl-2 and mcl-1/EAT mRNAs in all of the adrenal tumors. The expression levels differed greatly among the tumor samples. Mcl-1/EAT mRNA levels were enhanced in APA and CS compared with those in NF. In contrast, bcl-2 levels in NF were higher than in other tumors. Our results suggest that deregulation of such apoptosis-suppressing genes may contribute to the multistep tumorigenesis of human adrenal tumors and that mcl-1/EAT, one of the bcl-2 family genes, has a different role from that of bcl-2 in such pathways.

Original languageEnglish
Pages (from-to)955-960
Number of pages6
JournalEndocrine Research
Volume24
Issue number3-4
DOIs
Publication statusPublished - 1998 Jan 1

ASJC Scopus subject areas

  • Endocrinology

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    Ando, T., Shibata, H., Suzuki, T., Kurihara, I., Hayashi, K., Hayashi, M., Saito, I., Kawabe, H., Tsujioka, M., & Saruta, T. (1998). The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors. Endocrine Research, 24(3-4), 955-960. https://doi.org/10.3109/07435809809032715