TY - JOUR
T1 - The Potential Impact of Age on Gut Microbiota in Patients with Major Depressive Disorder
T2 - A Secondary Analysis of the Prospective Observational Study
AU - Miyaho, Katsuma
AU - Sanada, Kenji
AU - Kurokawa, Shunya
AU - Tanaka, Arisa
AU - Tachibana, Tomoyuki
AU - Ishii, Chiharu
AU - Noda, Yoshihiro
AU - Nakajima, Shinichiro
AU - Fukuda, Shinji
AU - Mimura, Masaru
AU - Kishimoto, Taishiro
AU - Iwanami, Akira
N1 - Funding Information:
This research was funded by the Japan Dairy Association (J-milk) (to K.S.); JSPS KAKENHI (18H04805 to S.F.), AMED-CREST (JP22gm1010009 to S.F.), JST ERATO (JPMJER1902 to S.F.), and the Food Science Institute Foundation (to S.F.).
Publisher Copyright:
© 2022 by the authors.
PY - 2022/11
Y1 - 2022/11
N2 - We aimed to investigate the impact of aging on the relationship among the composition of gut microbiota, gastrointestinal (GI) symptoms, and the course of treatment for major depressive disorder (MDD) by analyzing the datasets from our previous study. Patients with MDD were recruited, and their stools were collected at three time points (baseline, midterm, and endpoint) following the usual antidepressant treatment. Gut microbiota were analyzed using 16S rRNA gene sequencing. Patients were categorized into two groups based on their age: the late-life group over 60 years and the middle-aged group under 60 years. GI symptoms were assessed with scores of item 11 of the Hamilton Anxiety Rating Scale. One hundred and ninety samples were collected from 32 patients with MDD. Several gut microbes had higher relative abundances in the late-life group than in the middle-aged group. In addition, the late-life group showed significantly higher diversity in the Chao1 index at baseline compared with the middle-aged group. We further found possible microbial taxa related to GI symptoms in patients with late-life depression. The abundance of several bacterial taxa may contribute to GI symptoms in the late-life depression, and our findings suggest that the therapeutic targets for the application of gut microbiota may differ depending on the age group of patients with depression.
AB - We aimed to investigate the impact of aging on the relationship among the composition of gut microbiota, gastrointestinal (GI) symptoms, and the course of treatment for major depressive disorder (MDD) by analyzing the datasets from our previous study. Patients with MDD were recruited, and their stools were collected at three time points (baseline, midterm, and endpoint) following the usual antidepressant treatment. Gut microbiota were analyzed using 16S rRNA gene sequencing. Patients were categorized into two groups based on their age: the late-life group over 60 years and the middle-aged group under 60 years. GI symptoms were assessed with scores of item 11 of the Hamilton Anxiety Rating Scale. One hundred and ninety samples were collected from 32 patients with MDD. Several gut microbes had higher relative abundances in the late-life group than in the middle-aged group. In addition, the late-life group showed significantly higher diversity in the Chao1 index at baseline compared with the middle-aged group. We further found possible microbial taxa related to GI symptoms in patients with late-life depression. The abundance of several bacterial taxa may contribute to GI symptoms in the late-life depression, and our findings suggest that the therapeutic targets for the application of gut microbiota may differ depending on the age group of patients with depression.
KW - aging
KW - gastrointestinal symptoms
KW - gut microbiota
KW - major depressive disorder
KW - prospective study
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U2 - 10.3390/jpm12111827
DO - 10.3390/jpm12111827
M3 - Article
AN - SCOPUS:85141798094
SN - 2075-4426
VL - 12
JO - Journal of Personalized Medicine
JF - Journal of Personalized Medicine
IS - 11
M1 - 1827
ER -