The presence of anti-protein A antibodies in patients with rheumatoid arthritis

T. Takeuchi, O. Hosono, J. Koide, K. Amano, H. Sekine, T. Abe

Research output: Contribution to journalArticle

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Abstract

Sixteen patients with rheumatoid arthritis (RA) were examined for the presence of anti-protein A antibodies. The F(ab')2 preparations from five RA patients showed significant binding to IgG-free protein A on ELISA. The protein A binding was further examined by immunoblotting. The F(ab')2 preparations of high protein A-binding protein gave a specific reaction with IgG-free protein A on nitrocellulose paper. This demonstrates the presence of anti-protein A antibodies in patients with RA. Those RA patients with anti-protein A antibodies had more active disease as judged by the Lansbury's activity index. The level of serum rheumatoid factor (RAHA) was significantly higher in patients with anti-protein A antibodies than in those without anti-protein A antibodies.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalScandinavian Journal of Immunology
Volume33
Issue number5
Publication statusPublished - 1991
Externally publishedYes

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Staphylococcal Protein A
Rheumatoid Arthritis
Antibodies
Protein Binding
Immunoglobulin G
Collodion
Rheumatoid Factor
Immunoblotting
Carrier Proteins
Enzyme-Linked Immunosorbent Assay
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Takeuchi, T., Hosono, O., Koide, J., Amano, K., Sekine, H., & Abe, T. (1991). The presence of anti-protein A antibodies in patients with rheumatoid arthritis. Scandinavian Journal of Immunology, 33(5), 585-592.

The presence of anti-protein A antibodies in patients with rheumatoid arthritis. / Takeuchi, T.; Hosono, O.; Koide, J.; Amano, K.; Sekine, H.; Abe, T.

In: Scandinavian Journal of Immunology, Vol. 33, No. 5, 1991, p. 585-592.

Research output: Contribution to journalArticle

Takeuchi, T, Hosono, O, Koide, J, Amano, K, Sekine, H & Abe, T 1991, 'The presence of anti-protein A antibodies in patients with rheumatoid arthritis', Scandinavian Journal of Immunology, vol. 33, no. 5, pp. 585-592.
Takeuchi, T. ; Hosono, O. ; Koide, J. ; Amano, K. ; Sekine, H. ; Abe, T. / The presence of anti-protein A antibodies in patients with rheumatoid arthritis. In: Scandinavian Journal of Immunology. 1991 ; Vol. 33, No. 5. pp. 585-592.
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