The Presence of Anti‐Protein A Antibodies in Patients with Rheumatoid Arthritis

T. TAKEUCHI, O. HOSONO, J. KOIDE, K. AMANO, H. SEKINE, T. ABE

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4 Citations (Scopus)

Abstract

Sixteen patients with rheumatoid arthritis (RA) were examined for the presence of anti‐protein A antibodies. The F(ab′)2 preparations from five RA patients showed significant binding lo IgG‐free protein A on ELISA. The protein A binding was further examined by immunoblotting. The F(ab′)2 preparations of high protein A‐binding protein gave A specific reaction with IgG‐free protein A on nitrocellulose paper. This demonstrates the presence of anti‐protein A antibodies in patients with RA. Those RA patients with anti‐protein A antibodies had more active disease as judged by the Lansbury's activity index. The level of serum rheumatoid factor (RAHA) was significantly higher in patients with anti‐protein A antibodies than in those without anti‐protein A antibodies.

Original languageEnglish
Pages (from-to)585-592
Number of pages8
JournalScandinavian Journal of Immunology
Volume33
Issue number5
DOIs
Publication statusPublished - 1991 May
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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