The prevalence of overall and initial lymph node metastases in clinical t1n0 thoracic esophageal cancer: From the results of jcog0502, a prospective multicenter study

Yasunori Akutsu, Ken Kato, Hiroyasu Igaki, Yoshinori Ito, Isao Nozaki, Hiroyuki Daiko, Masahiko Yano, Harushi Udagawa, Satoru Nakagawa, Masakazu Takagi, Junki Mizusawa, Yuukou Kitagawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Objective: To evaluate the sites and frequencies of overall and initial lymph node (LN) metastases (LNMs) of clinical T1N0 esophageal cancer. Background: The sites and frequencies of initial LNMs and sentinel LNs (SLNs) of esophageal cancer remain unclear. Methods: The Japan Clinical Oncology Group JCOG0502 trial was a 4-arm prospective study that compared esophagectomy with chemoradiotherapy for clinical T1N0 esophageal cancer in both randomized and patient-preference arms. The preoperative diagnostic accuracy was evaluated for patients assigned to the surgery arm. Patients who withdrew consent and who were not treated were excluded. All patients underwent esophagectomy with D2 or greater LN dissection. From the pathologic findings, sites and frequencies of LNMs and SLNs were assessed and the frequency of skip LNMs was calculated. Results: In total, 211 patients underwent LNM and SLN analysis. Regarding N-factor accuracy, 57 (27.0%) of 211 clinical N0 cases had pathologic LNMs. The upper mediastinal and mediastinal/abdominal regions were frequent sites of LNMs in upper and lower thoracic cases, respectively. However, in middle thoracic cases, LNMs were observed in the neck, mediastinal, and abdominal regions, and pathologic SLN spread to all 3 fields. The frequency of skip LNMs was 36.7%. Conclusions: A clinical diagnosis of T1N0 is not sufficiently accurate, and therefore, it is unacceptable to omit LN dissection or minimize the prophylactic radiation field. SLNs, which are not location restricted, should be surveyed in all 3 fields.

Original languageEnglish
Pages (from-to)1009-1015
Number of pages7
JournalAnnals of Surgery
Volume264
Issue number6
DOIs
Publication statusPublished - 2016 Nov 28

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Esophageal Neoplasms
Multicenter Studies
Thorax
Lymph Nodes
Prospective Studies
Neoplasm Metastasis
Arm
Esophagectomy
Lymph Node Excision
Medical Oncology
Patient Preference
Chemoradiotherapy
Japan
Neck
cyhalothrin
Radiation

Keywords

  • Esophageal cancer
  • Lymph node dissection
  • Lymph node metastasis
  • Radiation field
  • Sentinel lymph node
  • Squamous cell carcinoma
  • T1N0

ASJC Scopus subject areas

  • Surgery

Cite this

The prevalence of overall and initial lymph node metastases in clinical t1n0 thoracic esophageal cancer : From the results of jcog0502, a prospective multicenter study. / Akutsu, Yasunori; Kato, Ken; Igaki, Hiroyasu; Ito, Yoshinori; Nozaki, Isao; Daiko, Hiroyuki; Yano, Masahiko; Udagawa, Harushi; Nakagawa, Satoru; Takagi, Masakazu; Mizusawa, Junki; Kitagawa, Yuukou.

In: Annals of Surgery, Vol. 264, No. 6, 28.11.2016, p. 1009-1015.

Research output: Contribution to journalArticle

Akutsu, Yasunori ; Kato, Ken ; Igaki, Hiroyasu ; Ito, Yoshinori ; Nozaki, Isao ; Daiko, Hiroyuki ; Yano, Masahiko ; Udagawa, Harushi ; Nakagawa, Satoru ; Takagi, Masakazu ; Mizusawa, Junki ; Kitagawa, Yuukou. / The prevalence of overall and initial lymph node metastases in clinical t1n0 thoracic esophageal cancer : From the results of jcog0502, a prospective multicenter study. In: Annals of Surgery. 2016 ; Vol. 264, No. 6. pp. 1009-1015.
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T1 - The prevalence of overall and initial lymph node metastases in clinical t1n0 thoracic esophageal cancer

T2 - From the results of jcog0502, a prospective multicenter study

AU - Akutsu, Yasunori

AU - Kato, Ken

AU - Igaki, Hiroyasu

AU - Ito, Yoshinori

AU - Nozaki, Isao

AU - Daiko, Hiroyuki

AU - Yano, Masahiko

AU - Udagawa, Harushi

AU - Nakagawa, Satoru

AU - Takagi, Masakazu

AU - Mizusawa, Junki

AU - Kitagawa, Yuukou

PY - 2016/11/28

Y1 - 2016/11/28

N2 - Objective: To evaluate the sites and frequencies of overall and initial lymph node (LN) metastases (LNMs) of clinical T1N0 esophageal cancer. Background: The sites and frequencies of initial LNMs and sentinel LNs (SLNs) of esophageal cancer remain unclear. Methods: The Japan Clinical Oncology Group JCOG0502 trial was a 4-arm prospective study that compared esophagectomy with chemoradiotherapy for clinical T1N0 esophageal cancer in both randomized and patient-preference arms. The preoperative diagnostic accuracy was evaluated for patients assigned to the surgery arm. Patients who withdrew consent and who were not treated were excluded. All patients underwent esophagectomy with D2 or greater LN dissection. From the pathologic findings, sites and frequencies of LNMs and SLNs were assessed and the frequency of skip LNMs was calculated. Results: In total, 211 patients underwent LNM and SLN analysis. Regarding N-factor accuracy, 57 (27.0%) of 211 clinical N0 cases had pathologic LNMs. The upper mediastinal and mediastinal/abdominal regions were frequent sites of LNMs in upper and lower thoracic cases, respectively. However, in middle thoracic cases, LNMs were observed in the neck, mediastinal, and abdominal regions, and pathologic SLN spread to all 3 fields. The frequency of skip LNMs was 36.7%. Conclusions: A clinical diagnosis of T1N0 is not sufficiently accurate, and therefore, it is unacceptable to omit LN dissection or minimize the prophylactic radiation field. SLNs, which are not location restricted, should be surveyed in all 3 fields.

AB - Objective: To evaluate the sites and frequencies of overall and initial lymph node (LN) metastases (LNMs) of clinical T1N0 esophageal cancer. Background: The sites and frequencies of initial LNMs and sentinel LNs (SLNs) of esophageal cancer remain unclear. Methods: The Japan Clinical Oncology Group JCOG0502 trial was a 4-arm prospective study that compared esophagectomy with chemoradiotherapy for clinical T1N0 esophageal cancer in both randomized and patient-preference arms. The preoperative diagnostic accuracy was evaluated for patients assigned to the surgery arm. Patients who withdrew consent and who were not treated were excluded. All patients underwent esophagectomy with D2 or greater LN dissection. From the pathologic findings, sites and frequencies of LNMs and SLNs were assessed and the frequency of skip LNMs was calculated. Results: In total, 211 patients underwent LNM and SLN analysis. Regarding N-factor accuracy, 57 (27.0%) of 211 clinical N0 cases had pathologic LNMs. The upper mediastinal and mediastinal/abdominal regions were frequent sites of LNMs in upper and lower thoracic cases, respectively. However, in middle thoracic cases, LNMs were observed in the neck, mediastinal, and abdominal regions, and pathologic SLN spread to all 3 fields. The frequency of skip LNMs was 36.7%. Conclusions: A clinical diagnosis of T1N0 is not sufficiently accurate, and therefore, it is unacceptable to omit LN dissection or minimize the prophylactic radiation field. SLNs, which are not location restricted, should be surveyed in all 3 fields.

KW - Esophageal cancer

KW - Lymph node dissection

KW - Lymph node metastasis

KW - Radiation field

KW - Sentinel lymph node

KW - Squamous cell carcinoma

KW - T1N0

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