TY - JOUR
T1 - The property of adhesion and biocompatibility of silicon and fluorine doped diamond-like carbon films
AU - Toyonaga, M.
AU - Hasebe, T.
AU - Maegawa, S.
AU - Matsumoto, T.
AU - Hotta, A.
AU - Suzuki, T.
N1 - Funding Information:
This study was partly supported by AMED (Japan Agency for Medical Research and Development) under Grant Number JP21hm0102059. We greatly appreciate the discussions with and helpful comments made by Mr. Shunsuke Kamei, Mr. Kosuke Tomita, Mr. Shota Yamamoto, Mr. Yuki Natsuyama and Mr. Kenta Bito at Tokai University, and Mr. Yuki Fujita at Onward Giken Co. and Mr. Kentaro Takeda, Mr. Yutaka Okamoto, Mr. Kosaku Yano and Mr. Yuya Oyama at Keio University.
Funding Information:
This study was partly supported by AMED (Japan Agency for Medical Research and Development) under Grant Number JP21hm0102059 . We greatly appreciate the discussions with and helpful comments made by Mr. Shunsuke Kamei, Mr. Kosuke Tomita, Mr. Shota Yamamoto, Mr. Yuki Natsuyama and Mr. Kenta Bito at Tokai University, and Mr. Yuki Fujita at Onward Giken Co., and Mr. Kentaro Takeda, Mr. Yutaka Okamoto, Mr. Kosaku Yano and Mr. Yuya Oyama at Keio University.
Publisher Copyright:
© 2021
PY - 2021/11
Y1 - 2021/11
N2 - Application of nickel‑titanium (NiTi) alloys to medical implant devices is increasing due to their unique characteristics. However, many reports show adverse effects of corrosion of the alloys due to implantation in human body. To ensure good biocompatibility in the human body, fluorine-doped amorphous carbon (a-C:H:F) coating is a promising candidate. Generally, a-C:H:F coating shows poor adhesion on metallic alloys, so that silicon-incorporated interlayer is introduced between a-C:H:F and metallic alloys. However, this membrane design has a risk of delamination at the outermost interface (a-C:H:F//interlayer), and also there is a practical problem that coating time becomes long because the deposition process in multiple stages is required. Here we develop silicon and fluorine doped amorphous carbon (a-C:H:Si:F) film which exhibits high adhesion and excellent biocompatibility. One of the a-C:H:Si:F films “C2H2-doped”, which was deposited using a mixture of TMS, C2H2 and C3F8, showed higher adhesive strength than a-C:H:F with Si-interlayer and the same number of adhesive platelets and leukocytes as a-C:H:F. This result demonstrated that a single film with both adhesion of Si-interlayer and biocompatibility of a-C:H:F was fabricated. Furthermore, this a-C:H:Si:F coating can be anticipated as an effective film coating method in a practical point of view, because the film deposition is completed in one process.
AB - Application of nickel‑titanium (NiTi) alloys to medical implant devices is increasing due to their unique characteristics. However, many reports show adverse effects of corrosion of the alloys due to implantation in human body. To ensure good biocompatibility in the human body, fluorine-doped amorphous carbon (a-C:H:F) coating is a promising candidate. Generally, a-C:H:F coating shows poor adhesion on metallic alloys, so that silicon-incorporated interlayer is introduced between a-C:H:F and metallic alloys. However, this membrane design has a risk of delamination at the outermost interface (a-C:H:F//interlayer), and also there is a practical problem that coating time becomes long because the deposition process in multiple stages is required. Here we develop silicon and fluorine doped amorphous carbon (a-C:H:Si:F) film which exhibits high adhesion and excellent biocompatibility. One of the a-C:H:Si:F films “C2H2-doped”, which was deposited using a mixture of TMS, C2H2 and C3F8, showed higher adhesive strength than a-C:H:F with Si-interlayer and the same number of adhesive platelets and leukocytes as a-C:H:F. This result demonstrated that a single film with both adhesion of Si-interlayer and biocompatibility of a-C:H:F was fabricated. Furthermore, this a-C:H:Si:F coating can be anticipated as an effective film coating method in a practical point of view, because the film deposition is completed in one process.
KW - Anti-thrombogenic
KW - Biomaterials
KW - Biomedical applications
KW - Diamond-like carbon
UR - http://www.scopus.com/inward/record.url?scp=85113276654&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85113276654&partnerID=8YFLogxK
U2 - 10.1016/j.diamond.2021.108558
DO - 10.1016/j.diamond.2021.108558
M3 - Review article
AN - SCOPUS:85113276654
VL - 119
JO - Diamond and Related Materials
JF - Diamond and Related Materials
SN - 0925-9635
M1 - 108558
ER -