The Prophylactic Effect of Oral Olanzapine on Postoperative Nausea and Vomiting in Laparoscopic Gynecological Surgery: A Randomized Clinical Trial

Hiroyuki Seki, Norifumi Kuratani, Toshiya Shiga, Norikazu Miura, Ichiro Kondo, Mao Kinoshita, Yoshiki Sento, Yuya Masuda, Sathoshi Ideno, Kohei Ikeda, Koji Takano, Yuuki Kuwabara, Rie Kinugasa, Fumimasa Amaya, Teiji Sawa, Kazuya Sobue, Hiroshi Morisaki

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although the antiemetic effect of olanzapine on chemotherapy-induced nausea and vomiting has been characterized, the prophylactic role of olanzapine on postoperative nausea and vomiting (PONV) has not been fully elucidated. This clinical trial aims to examine the effectiveness of olanzapine for preventing PONV. Methods: Patients undergoing laparoscopic gynecological surgery at 5 university hospitals in Japan will be randomly assigned to receive either 5 mg of oral olanzapine or placebo 2 hours before the induction of anesthesia. All patients will receive intravenous dexamethasone at the induction of anesthesia. The primary outcome will be the incidence of postoperative nausea and vomiting within 24 hours after surgery. Secondary endpoints will include longitudinal changes in the incidence of postoperative nausea and vomiting and overall patient satisfaction. Discussion: This trial will provide a high quality evidence whether olanzapine prevents PONV in gynecological laparoscopy patients at a high risk for PONV. Ethics and dissemination: The trial was approved by the institutional review board of the each participating study site. Study findings will be disseminated through peer-reviewed publications and in conference presentations.

Original languageEnglish
JournalUnknown Journal
DOIs
Publication statusPublished - 2020 Nov 30

ASJC Scopus subject areas

  • Medicine(all)

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