The (Pro)Renin Receptor and the Kidney

Atsuhiro Ichihara, Yuki Kaneshiro, Tomoko Takemitsu, Mariyo Sakoda, Hiroshi Itoh

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Prorenin binding to the (pro)renin receptor not only causes a nonproteolytic activation of prorenin leading to the activation of the renin-angiotensin system (RAS), but also stimulates the receptor's own intracellular signaling pathways independent of the RAS. Within the kidneys, the (pro)renin receptor is present in the glomerular mesangium and podocytes, which play an important role in the maintenance of the glomerular filtration barrier. Therefore, prorenin-receptor blockers, which competitively bind to the receptor as a decoy peptide, have superior benefits with regard to proteinuria and glomerulosclerosis in experimental animal models with elevated plasma prorenin levels such as diabetes and hypertension compared with conventional RAS inhibitors, possibly by inhibiting both the nonproteolytic activation of prorenin and RAS-independent intracellular signals.

Original languageEnglish
Pages (from-to)524-528
Number of pages5
JournalSeminars in Nephrology
Volume27
Issue number5
DOIs
Publication statusPublished - 2007 Sep 1

    Fingerprint

Keywords

  • Angiotensin
  • mesangium
  • nonproteolytic activation
  • podocytes
  • prorenin

ASJC Scopus subject areas

  • Nephrology

Cite this

Ichihara, A., Kaneshiro, Y., Takemitsu, T., Sakoda, M., & Itoh, H. (2007). The (Pro)Renin Receptor and the Kidney. Seminars in Nephrology, 27(5), 524-528. https://doi.org/10.1016/j.semnephrol.2007.07.005