The reactive intermediate of catalytic borohydride reduction by Schiff base-cobalt complexes

Izumi Iwakura, Miho Hatanaka, Ai Kokura, Haruna Teraoka, Taketo Ikeno, Takushi Nagata, Tohru Yamada

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20 Citations (Scopus)

Abstract

The key reactive intermediate of borohydride reduction catalyzed by Schiff base-cobalt complexes is proposed to be the dichloromethylcobalt hydride with a sodium cation, based on experimental and theoretical studies. It was revealed that chloroform is not the solvent but the reactant that activates the cobalt catalyst. The substrate carbonyl compounds are fixed and activated by the alkali cation, which is cap tured by the oxygen atoms of the planar ligand and the chlorine atom of the axial ligand, and attacked by the hydride on the cobalt atom via a sixmembered-like transition state to afford the corresponding alcohol.

Original languageEnglish
Pages (from-to)656-663
Number of pages8
JournalChemistry - An Asian Journal
Volume1
Issue number5
DOIs
Publication statusPublished - 2006

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Keywords

  • Asymmetric synthesis
  • Cobalt
  • Density functional calculations
  • Reduction
  • Schiff bases

ASJC Scopus subject areas

  • Chemistry(all)

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