Abstract
The key reactive intermediate of borohydride reduction catalyzed by Schiff base-cobalt complexes is proposed to be the dichloromethylcobalt hydride with a sodium cation, based on experimental and theoretical studies. It was revealed that chloroform is not the solvent but the reactant that activates the cobalt catalyst. The substrate carbonyl compounds are fixed and activated by the alkali cation, which is cap tured by the oxygen atoms of the planar ligand and the chlorine atom of the axial ligand, and attacked by the hydride on the cobalt atom via a sixmembered-like transition state to afford the corresponding alcohol.
| Original language | English |
|---|---|
| Pages (from-to) | 656-663 |
| Number of pages | 8 |
| Journal | Chemistry - An Asian Journal |
| Volume | 1 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2006 |
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Keywords
- Asymmetric synthesis
- Cobalt
- Density functional calculations
- Reduction
- Schiff bases
ASJC Scopus subject areas
- Chemistry(all)
Cite this
The reactive intermediate of catalytic borohydride reduction by Schiff base-cobalt complexes. / Iwakura, Izumi; Hatanaka, Miho; Kokura, Ai; Teraoka, Haruna; Ikeno, Taketo; Nagata, Takushi; Yamada, Tohru.
In: Chemistry - An Asian Journal, Vol. 1, No. 5, 2006, p. 656-663.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The reactive intermediate of catalytic borohydride reduction by Schiff base-cobalt complexes
AU - Iwakura, Izumi
AU - Hatanaka, Miho
AU - Kokura, Ai
AU - Teraoka, Haruna
AU - Ikeno, Taketo
AU - Nagata, Takushi
AU - Yamada, Tohru
PY - 2006
Y1 - 2006
N2 - The key reactive intermediate of borohydride reduction catalyzed by Schiff base-cobalt complexes is proposed to be the dichloromethylcobalt hydride with a sodium cation, based on experimental and theoretical studies. It was revealed that chloroform is not the solvent but the reactant that activates the cobalt catalyst. The substrate carbonyl compounds are fixed and activated by the alkali cation, which is cap tured by the oxygen atoms of the planar ligand and the chlorine atom of the axial ligand, and attacked by the hydride on the cobalt atom via a sixmembered-like transition state to afford the corresponding alcohol.
AB - The key reactive intermediate of borohydride reduction catalyzed by Schiff base-cobalt complexes is proposed to be the dichloromethylcobalt hydride with a sodium cation, based on experimental and theoretical studies. It was revealed that chloroform is not the solvent but the reactant that activates the cobalt catalyst. The substrate carbonyl compounds are fixed and activated by the alkali cation, which is cap tured by the oxygen atoms of the planar ligand and the chlorine atom of the axial ligand, and attacked by the hydride on the cobalt atom via a sixmembered-like transition state to afford the corresponding alcohol.
KW - Asymmetric synthesis
KW - Cobalt
KW - Density functional calculations
KW - Reduction
KW - Schiff bases
UR - http://www.scopus.com/inward/record.url?scp=33845246832&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845246832&partnerID=8YFLogxK
U2 - 10.1002/asia.200600150
DO - 10.1002/asia.200600150
M3 - Article
C2 - 17441105
AN - SCOPUS:33845246832
VL - 1
SP - 656
EP - 663
JO - Chemistry - An Asian Journal
JF - Chemistry - An Asian Journal
SN - 1861-4728
IS - 5
ER -