TY - JOUR
T1 - The recipient CCR5 variation predicts survival outcomes after bone marrow transplantation
AU - Horio, Tomohiro
AU - Mizuno, Shohei
AU - Uchino, Kaori
AU - Mizutani, Motonori
AU - Hanamura, Ichiro
AU - Espinoza, J. Luis
AU - Onizuka, Makoto
AU - Kashiwase, Koichi
AU - Morishima, Yasuo
AU - Fukuda, Takahiro
AU - Kodera, Yoshihisa
AU - Doki, Noriko
AU - Miyamura, Koichi
AU - Mori, Takehiko
AU - Takami, Akiyoshi
PY - 2017/6
Y1 - 2017/6
N2 - The chemokine receptor CCR5 plays roles in the trafficking of effector cells towards the site of inflammation. We retrospectively examined the impact of the CCR5 variation (rs1800023, -2086A > G) on transplant outcomes in a cohort of 329 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. A multivariate analysis showed that the recipient CCR5 -2086A/A genotype was significantly associated with a lower relapse rate but not with the development of graft-versus-host disease (GVHD) or transplant-related mortality, thereby resulting in better disease-free and overall survival rates than other variations. The donor CCR5 -2086A/A genotype was associated with a lower incidence of grades 3–4 acute GVHD, which did not improve the survival outcomes. These findings suggest that the recipient CCR5 -2086A/A genotype affects the induction of the graft-versus-tumor effect without augmenting the development of GVHD. CCR5 genotyping in transplant recipients may therefore be a useful tool for evaluating pretransplantation risks.
AB - The chemokine receptor CCR5 plays roles in the trafficking of effector cells towards the site of inflammation. We retrospectively examined the impact of the CCR5 variation (rs1800023, -2086A > G) on transplant outcomes in a cohort of 329 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. A multivariate analysis showed that the recipient CCR5 -2086A/A genotype was significantly associated with a lower relapse rate but not with the development of graft-versus-host disease (GVHD) or transplant-related mortality, thereby resulting in better disease-free and overall survival rates than other variations. The donor CCR5 -2086A/A genotype was associated with a lower incidence of grades 3–4 acute GVHD, which did not improve the survival outcomes. These findings suggest that the recipient CCR5 -2086A/A genotype affects the induction of the graft-versus-tumor effect without augmenting the development of GVHD. CCR5 genotyping in transplant recipients may therefore be a useful tool for evaluating pretransplantation risks.
KW - Bone marrow transplantation
KW - CCR5
KW - Graft-versus-host disease
KW - Single nucleotide variation
KW - Unrelated donor
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U2 - 10.1016/j.trim.2017.05.003
DO - 10.1016/j.trim.2017.05.003
M3 - Article
C2 - 28487238
AN - SCOPUS:85019076279
VL - 42
SP - 34
EP - 39
JO - Transplant Immunology
JF - Transplant Immunology
SN - 0966-3274
ER -