The recurrence of malignant pleural mesothelioma 14 years after extrapleural pneumonectomy: Possible histological transformation

Tomonari Kinoshita, Genichiro Ishii, Yuki Matsumura, Toshihiro Shiozawa, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Kanji Nagai

Research output: Contribution to journalArticle

1 Citation (Scopus)


A 56-year-old man underwent extrapleural pneumonectomy for malignant pleural mesothelioma (MPM). The histological diagnosis was epithelioid mesothelioma with T2N0M0, and no sarcomatoid component was observed. Subsequently, 14years after complete resection, screening computed tomography detected a rapidly growing right thoracic mass, which was diagnosed as a recurrence of MPM on resection. However, it was composed of both epithelioid (50%) and sarcomatoid (50%) components, suggesting possible histological transformation. Although there have been some previous reports on the recurrence of MPM, to the best of our knowledge, this is the first clinical case which indicated that histological transformation of MPM might occur.

Original languageEnglish
Pages (from-to)754-757
Number of pages4
JournalPathology International
Issue number11
Publication statusPublished - 2012 Nov
Externally publishedYes



  • Biphasic type
  • Epithelioid type
  • Histological transformation
  • Mesothelioma
  • Sarcomatoid type

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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