The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE study

Daisuke Sugiyama, Aya Higashiyama, Ichiro Wakabayashi, Yoshimi Kubota, Yoshiko Adachi, Akiko Hayashibe, Kuniko Kawamura, Kazuyo Kuwabara, Kunihiro Nishimura, Aya Kadota, Yoko Nishida, Takumi Hirata, Hironori Imano, Naomi Miyamatsu, Yoshihiro Miyamoto, Tatsuya Sawamura, Tomonori Okamura

Research output: Contribution to journalArticle

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Abstract

Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardioankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1- related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX- 1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p= 0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.

Original languageEnglish
Pages (from-to)499-508
Number of pages10
JournalJournal of Atherosclerosis and Thrombosis
Volume22
Issue number5
Publication statusPublished - 2015

Fingerprint

Oxidized LDL Receptors
Class E Scavenger Receptors
Apolipoproteins B
LDL Lipoproteins
Ankle
Blood Vessels
Ligands
Plasmas
Atherosclerosis
Cardiovascular Diseases
Medical problems
Linear regression
LDL Cholesterol
Dyslipidemias
Linear Models
Regression Analysis
Hypertension

Keywords

  • Cardio-ankle vascular index
  • Community-based study
  • Lectin-like oxidized low-density lipoprotein receptor-1
  • LOX-1 ligand containing ApoB

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants : The KOBE study. / Sugiyama, Daisuke; Higashiyama, Aya; Wakabayashi, Ichiro; Kubota, Yoshimi; Adachi, Yoshiko; Hayashibe, Akiko; Kawamura, Kuniko; Kuwabara, Kazuyo; Nishimura, Kunihiro; Kadota, Aya; Nishida, Yoko; Hirata, Takumi; Imano, Hironori; Miyamatsu, Naomi; Miyamoto, Yoshihiro; Sawamura, Tatsuya; Okamura, Tomonori.

In: Journal of Atherosclerosis and Thrombosis, Vol. 22, No. 5, 2015, p. 499-508.

Research output: Contribution to journalArticle

Sugiyama, D, Higashiyama, A, Wakabayashi, I, Kubota, Y, Adachi, Y, Hayashibe, A, Kawamura, K, Kuwabara, K, Nishimura, K, Kadota, A, Nishida, Y, Hirata, T, Imano, H, Miyamatsu, N, Miyamoto, Y, Sawamura, T & Okamura, T 2015, 'The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants: The KOBE study', Journal of Atherosclerosis and Thrombosis, vol. 22, no. 5, pp. 499-508.
Sugiyama, Daisuke ; Higashiyama, Aya ; Wakabayashi, Ichiro ; Kubota, Yoshimi ; Adachi, Yoshiko ; Hayashibe, Akiko ; Kawamura, Kuniko ; Kuwabara, Kazuyo ; Nishimura, Kunihiro ; Kadota, Aya ; Nishida, Yoko ; Hirata, Takumi ; Imano, Hironori ; Miyamatsu, Naomi ; Miyamoto, Yoshihiro ; Sawamura, Tatsuya ; Okamura, Tomonori. / The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants : The KOBE study. In: Journal of Atherosclerosis and Thrombosis. 2015 ; Vol. 22, No. 5. pp. 499-508.
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abstract = "Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardioankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1- related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX- 1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p= 0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.",
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T1 - The relationship between lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B and the cardio-ankle vascular index in healthy community inhabitants

T2 - The KOBE study

AU - Sugiyama, Daisuke

AU - Higashiyama, Aya

AU - Wakabayashi, Ichiro

AU - Kubota, Yoshimi

AU - Adachi, Yoshiko

AU - Hayashibe, Akiko

AU - Kawamura, Kuniko

AU - Kuwabara, Kazuyo

AU - Nishimura, Kunihiro

AU - Kadota, Aya

AU - Nishida, Yoko

AU - Hirata, Takumi

AU - Imano, Hironori

AU - Miyamatsu, Naomi

AU - Miyamoto, Yoshihiro

AU - Sawamura, Tatsuya

AU - Okamura, Tomonori

PY - 2015

Y1 - 2015

N2 - Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardioankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1- related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX- 1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p= 0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.

AB - Aims: Lectin-like oxidized low-density lipoprotein (LDL) receptor-1 ligands containing apolipoprotein B (LAB) and lectin-like oxidized LDL receptor-1 (LOX-1) are known as LOX-1-related modified LDL indicators. These indicators play an important role in the early phase atherosclerosis, but the relationship between these indicators and subclinical atherosclerosis, as represented by the cardioankle vascular index (CAVI), has not been assessed. We herein investigated the association of LOX-1- related modified LDL indicators and the CAVI in healthy, Japanese urban community inhabitants who were considered to be at low risk for cardiovascular disease (CVD). Methods: The participants were 515 healthy Japanese (310 men and 205 women) without a history of CVD, cancer or the use of medication for hypertension, diabetes or dyslipidaemia. To estimate the association between LOX-1-related modified LDL indicators (LAB, soluble form of LOX-1 (sLOX- 1)) and the CAVI, we performed multivariable linear regression analyses with possible confounders such as the serum LDL cholesterol level. Results: The plasma LAB showed a positive association with the CAVI in men (standardized coefficient: 0.11, p= 0.04). This relationship was not observed in women. On the other hand, no clear association was observed between the CAVI and the plasma sLOX-1 level in either sex. Conclusions: The plasma LAB levels may represent a useful marker for detecting potential atherosclerosis in healthy individuals considered to be at low risk for atherosclerosis and CVD. Further studies are needed to confirm the present findings.

KW - Cardio-ankle vascular index

KW - Community-based study

KW - Lectin-like oxidized low-density lipoprotein receptor-1

KW - LOX-1 ligand containing ApoB

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