The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese

S. Higuchi, Taro Muramatsu, K. Shigemori, M. Saito, H. Kono, M. C. Dufour, T. C. Harford

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The relationship between the low Km aldehyde dehydrogenase (ALDH2) phenotype determined by the isoelectric focusing of hair root lysates, facial flushing and alcohol drinking patterns in Japanese (N = 282) was examined. Men who had inactive ALDH2 drank significantly less alcohol than those with active ALDH2. Although the effect was less noticeable, a similar relationship was detected in women. Two types of flushing responses were determined: one due to the inactive ALDH2, the other unrelated to this variant form of the isozyme. A striking difference between these flushing types, in terms of the inhibitory influence over drinking patterns, was noted. Nearly 86% of the subjects who reported always flushing in the face were shown to have inactive ALDH2, whereas infrequent flushing and absence of flushing were associated with active ALDH2. Thus, facial flushing may be used as an indicator of ALDH2 phenotype.

Original languageEnglish
Pages (from-to)170-175
Number of pages6
JournalJournal of Studies on Alcohol
Volume53
Issue number2
Publication statusPublished - 1992
Externally publishedYes

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Drinking Behavior
Aldehyde Dehydrogenase
alcohol
Alcohols
Phenotype
Isoelectric Focusing
Alcohol Drinking
Hair
Isoenzymes
Drinking

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychology(all)

Cite this

Higuchi, S., Muramatsu, T., Shigemori, K., Saito, M., Kono, H., Dufour, M. C., & Harford, T. C. (1992). The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. Journal of Studies on Alcohol, 53(2), 170-175.

The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. / Higuchi, S.; Muramatsu, Taro; Shigemori, K.; Saito, M.; Kono, H.; Dufour, M. C.; Harford, T. C.

In: Journal of Studies on Alcohol, Vol. 53, No. 2, 1992, p. 170-175.

Research output: Contribution to journalArticle

Higuchi, S, Muramatsu, T, Shigemori, K, Saito, M, Kono, H, Dufour, MC & Harford, TC 1992, 'The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese', Journal of Studies on Alcohol, vol. 53, no. 2, pp. 170-175.
Higuchi, S. ; Muramatsu, Taro ; Shigemori, K. ; Saito, M. ; Kono, H. ; Dufour, M. C. ; Harford, T. C. / The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. In: Journal of Studies on Alcohol. 1992 ; Vol. 53, No. 2. pp. 170-175.
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