The reorganization of functional architecture in the early-stages of Parkinson's disease

Noora Tuovinen, Klaus Seppi, Francesco de Pasquale, Christoph Müller, Michael Nocker, Michael Schocke, Elke R. Gizewski, Christian Kremser, Gregor K. Wenning, Werner Poewe, Atbin Djamshidian, Christoph Scherfler, Morinobu Seki

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. Methods: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0.3 years. Resting-state fMRI analysis included region-to-region connectivity in correlation with UPDRS-III scores and computation of Global Efficiency and Degree Centrality. Results: At baseline, patients' connectivity increased between the cerebellum and somatomotor network, and decreased between motor regions (Rolandic operculum, precentral gyrus, supplementary motor area, postcentral gyrus) and cingulate connectivity. At 1.5 years follow-up, connectivity remained altered in the same regions identified at baseline. The cerebellum showed additional hyperconnectivity within itself and to the caudate nucleus, thalamus and amygdala compared to controls. These differences correlated with UPDRS-III scores. Seed-based connectivity revealed increased involvement of the default mode network with precentral gyrus in patients at follow-up investigation. Conclusion: Resting-state fMRI identified marked disturbances of the overall architecture of connectivity in Parkinson's disease. The noted alterations in cortical motor areas were associated with cerebellar hyperconnectivity in early to moderately advanced stages of Parkinson's disease suggesting ongoing attempts of recovery and compensatory mechanism for affected functions. The potential to identify connectivity alterations in regions related to both motor and attentional functions requires further evaluation as an objective marker to monitor disease progression, and medical, as well as surgical interventions.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalParkinsonism and Related Disorders
Volume50
DOIs
Publication statusPublished - 2018 May 1
Externally publishedYes

Fingerprint

Parkinson Disease
Magnetic Resonance Imaging
Motor Cortex
Frontal Lobe
Cerebellum
Somatosensory Cortex
Caudate Nucleus
Amygdala
Thalamus
Disease Progression
Seeds
Healthy Volunteers

Keywords

  • Functional brain connectivity
  • Functional magnetic resonance imaging (fMRI)
  • Longitudinal
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

The reorganization of functional architecture in the early-stages of Parkinson's disease. / Tuovinen, Noora; Seppi, Klaus; de Pasquale, Francesco; Müller, Christoph; Nocker, Michael; Schocke, Michael; Gizewski, Elke R.; Kremser, Christian; Wenning, Gregor K.; Poewe, Werner; Djamshidian, Atbin; Scherfler, Christoph; Seki, Morinobu.

In: Parkinsonism and Related Disorders, Vol. 50, 01.05.2018, p. 61-68.

Research output: Contribution to journalArticle

Tuovinen, N, Seppi, K, de Pasquale, F, Müller, C, Nocker, M, Schocke, M, Gizewski, ER, Kremser, C, Wenning, GK, Poewe, W, Djamshidian, A, Scherfler, C & Seki, M 2018, 'The reorganization of functional architecture in the early-stages of Parkinson's disease', Parkinsonism and Related Disorders, vol. 50, pp. 61-68. https://doi.org/10.1016/j.parkreldis.2018.02.013
Tuovinen, Noora ; Seppi, Klaus ; de Pasquale, Francesco ; Müller, Christoph ; Nocker, Michael ; Schocke, Michael ; Gizewski, Elke R. ; Kremser, Christian ; Wenning, Gregor K. ; Poewe, Werner ; Djamshidian, Atbin ; Scherfler, Christoph ; Seki, Morinobu. / The reorganization of functional architecture in the early-stages of Parkinson's disease. In: Parkinsonism and Related Disorders. 2018 ; Vol. 50. pp. 61-68.
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AU - Schocke, Michael

AU - Gizewski, Elke R.

AU - Kremser, Christian

AU - Wenning, Gregor K.

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AU - Djamshidian, Atbin

AU - Scherfler, Christoph

AU - Seki, Morinobu

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N2 - Introduction: The study aim was to identify longitudinal abnormalities of functional connectivity and its relation with motor disability in early to moderately advanced stages of Parkinson's disease patients. Methods: 3.0T structural and resting-state functional MRI was performed in healthy subjects (n = 16) and Parkinson's disease patients (n = 16) with mean disease duration of 2.2 ± 1.2 years at baseline with a clinical follow-up of 1.5 ± 0.3 years. Resting-state fMRI analysis included region-to-region connectivity in correlation with UPDRS-III scores and computation of Global Efficiency and Degree Centrality. Results: At baseline, patients' connectivity increased between the cerebellum and somatomotor network, and decreased between motor regions (Rolandic operculum, precentral gyrus, supplementary motor area, postcentral gyrus) and cingulate connectivity. At 1.5 years follow-up, connectivity remained altered in the same regions identified at baseline. The cerebellum showed additional hyperconnectivity within itself and to the caudate nucleus, thalamus and amygdala compared to controls. These differences correlated with UPDRS-III scores. Seed-based connectivity revealed increased involvement of the default mode network with precentral gyrus in patients at follow-up investigation. Conclusion: Resting-state fMRI identified marked disturbances of the overall architecture of connectivity in Parkinson's disease. The noted alterations in cortical motor areas were associated with cerebellar hyperconnectivity in early to moderately advanced stages of Parkinson's disease suggesting ongoing attempts of recovery and compensatory mechanism for affected functions. The potential to identify connectivity alterations in regions related to both motor and attentional functions requires further evaluation as an objective marker to monitor disease progression, and medical, as well as surgical interventions.

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