The RET proto-oncogene in sporadic pheochromocytomas

Kazuhiko Takaya, Takaaki Yoshimasa, Hiroshi Arai, Naohisa Tamura, Yoshihiro Miyamoto, Hiroshi Itoh, Kazuwa Nakao

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In order to evaluate the role of RET proto-oncogene in the development and growth of pheochromocytomas, we examined mutations in RET and expression of RET in 7 cases of sporadic pheochromocytomas. Tumors were screened for mutations in exons 10 and 11 and codon 918 which are identified in multiple endocrine neoplasia types 2A and 2B. No mutations were found in these regions in all of the sporadic pheochromocytomas examined. On the other hand, RET mRNA was detected in all pheochromocytomas and the levels of RET expression were higher in 5 of 7 pheochromocytomas than in normal adrenal medulla, indicating that RET is overexpressed in a sizable portion of sporadic pheochromocytomas. These results suggest that high levels of expression of RET may have relevance to the development or growth of sporadic pheochromocytomas.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalInternal Medicine
Volume35
Issue number6
DOIs
Publication statusPublished - 1996 Jun
Externally publishedYes

Keywords

  • Adrenal medulla
  • Gene expression
  • Mutation
  • c-fos
  • c-myc

ASJC Scopus subject areas

  • Internal Medicine

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