The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki, Tatsuya Moriyama, Hideyuki Shimizu, Kazunori Inuzuka, Tetsumei Urano, Naoki Unno

Research output: Contribution to journalReview article

Abstract

Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

Original languageEnglish
Pages (from-to)382-390
Number of pages9
JournalAnnals of Vascular Surgery
Volume63
DOIs
Publication statusPublished - 2020 Feb

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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    Tanaka, H., Zaima, N., Kugo, H., Yata, T., Iida, Y., Hashimoto, K., Miyamoto, C., Sasaki, T., Sano, H., Suzuki, Y., Moriyama, T., Shimizu, H., Inuzuka, K., Urano, T., & Unno, N. (2020). The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model. Annals of Vascular Surgery, 63, 382-390. https://doi.org/10.1016/j.avsg.2019.08.082