The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki, Tatsuya Moriyama, Hideyuki Shimizu, Kazunori Inuzuka, Tetsumei Urano, Naoki Unno

Research output: Contribution to journalReview article

Abstract

Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

Original languageEnglish
JournalAnnals of Vascular Surgery
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Abdominal Aortic Aneurysm
Rupture
Animal Models
Pathology
Vasa Vasorum
Abdominal Aorta
Dilatation
Shock
Inflammation

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms : Development of a Novel Rupture Mechanism Model. / Tanaka, Hiroki; Zaima, Nobuhiro; Kugo, Hirona; Yata, Tatsuro; Iida, Yasunori; Hashimoto, Keisuke; Miyamoto, Chie; Sasaki, Takeshi; Sano, Hideto; Suzuki, Yuko; Moriyama, Tatsuya; Shimizu, Hideyuki; Inuzuka, Kazunori; Urano, Tetsumei; Unno, Naoki.

In: Annals of Vascular Surgery, 01.01.2019.

Research output: Contribution to journalReview article

Tanaka, H, Zaima, N, Kugo, H, Yata, T, Iida, Y, Hashimoto, K, Miyamoto, C, Sasaki, T, Sano, H, Suzuki, Y, Moriyama, T, Shimizu, H, Inuzuka, K, Urano, T & Unno, N 2019, 'The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model', Annals of Vascular Surgery. https://doi.org/10.1016/j.avsg.2019.08.082
Tanaka, Hiroki ; Zaima, Nobuhiro ; Kugo, Hirona ; Yata, Tatsuro ; Iida, Yasunori ; Hashimoto, Keisuke ; Miyamoto, Chie ; Sasaki, Takeshi ; Sano, Hideto ; Suzuki, Yuko ; Moriyama, Tatsuya ; Shimizu, Hideyuki ; Inuzuka, Kazunori ; Urano, Tetsumei ; Unno, Naoki. / The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms : Development of a Novel Rupture Mechanism Model. In: Annals of Vascular Surgery. 2019.
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AU - Kugo, Hirona

AU - Yata, Tatsuro

AU - Iida, Yasunori

AU - Hashimoto, Keisuke

AU - Miyamoto, Chie

AU - Sasaki, Takeshi

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AU - Suzuki, Yuko

AU - Moriyama, Tatsuya

AU - Shimizu, Hideyuki

AU - Inuzuka, Kazunori

AU - Urano, Tetsumei

AU - Unno, Naoki

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