The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka; Nobuhiro Zaima; Hirona Kugo; Tatsuro Yata; Yasunori Iida; Keisuke Hashimoto; Chie Miyamoto; Takeshi Sasaki; Hideto Sano; Yuko Suzuki; Tatsuya Moriyama; Hideyuki Shimizu; Kazunori Inuzuka; Tetsumei Urano; Naoki Unno

doi:10.1016/j.avsg.2019.08.082

The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

Hiroki Tanaka, Nobuhiro Zaima, Hirona Kugo, Tatsuro Yata, Yasunori Iida, Keisuke Hashimoto, Chie Miyamoto, Takeshi Sasaki, Hideto Sano, Yuko Suzuki, Tatsuya Moriyama, Hideyuki Shimizu, Kazunori Inuzuka, Tetsumei Urano, Naoki Unno

Department of Surgery (Cardiovascular Surgery)

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

Original language	English
Pages (from-to)	382-390
Number of pages	9
Journal	Annals of Vascular Surgery
Volume	63
DOIs	https://doi.org/10.1016/j.avsg.2019.08.082
Publication status	Published - 2020 Feb

ASJC Scopus subject areas

Surgery
Cardiology and Cardiovascular Medicine

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Tanaka, H., Zaima, N., Kugo, H., Yata, T., Iida, Y., Hashimoto, K., Miyamoto, C., Sasaki, T., Sano, H., Suzuki, Y., Moriyama, T., Shimizu, H., Inuzuka, K., Urano, T., & Unno, N. (2020). The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model. Annals of Vascular Surgery, 63, 382-390. https://doi.org/10.1016/j.avsg.2019.08.082

Tanaka, H, Zaima, N, Kugo, H, Yata, T, Iida, Y, Hashimoto, K, Miyamoto, C, Sasaki, T, Sano, H, Suzuki, Y, Moriyama, T, Shimizu, H, Inuzuka, K, Urano, T & Unno, N 2020, 'The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model', Annals of Vascular Surgery, vol. 63, pp. 382-390. https://doi.org/10.1016/j.avsg.2019.08.082

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title = "The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model",

abstract = "Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.",

author = "Hiroki Tanaka and Nobuhiro Zaima and Hirona Kugo and Tatsuro Yata and Yasunori Iida and Keisuke Hashimoto and Chie Miyamoto and Takeshi Sasaki and Hideto Sano and Yuko Suzuki and Tatsuya Moriyama and Hideyuki Shimizu and Kazunori Inuzuka and Tetsumei Urano and Naoki Unno",

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year = "2020",

month = feb,

doi = "10.1016/j.avsg.2019.08.082",

language = "English",

volume = "63",

pages = "382--390",

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T2 - Development of a Novel Rupture Mechanism Model

AU - Tanaka, Hiroki

AU - Zaima, Nobuhiro

AU - Kugo, Hirona

AU - Yata, Tatsuro

AU - Iida, Yasunori

AU - Hashimoto, Keisuke

AU - Miyamoto, Chie

AU - Sasaki, Takeshi

AU - Sano, Hideto

AU - Suzuki, Yuko

AU - Moriyama, Tatsuya

AU - Shimizu, Hideyuki

AU - Inuzuka, Kazunori

AU - Urano, Tetsumei

AU - Unno, Naoki

PY - 2020/2

Y1 - 2020/2

N2 - Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

AB - Existing animal models do not replicate all aspects of abdominal aortic aneurysms (AAAs), including the rupture mechanisms. From histopathological analyses conducted in humans, it has been found that the vasa vasorum of the AAA wall is the starting point of circulatory failure and that bulging and dilatation of the abdominal aorta occurs through inflammation and tissue degeneration. We created a new animal model (the hypoperfusion-induced model) of AAAs. In this study, we describe the current animal models of AAAs and present the utility of our new model of AAAs.

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The Role of Animal Models in Elucidating the Etiology and Pathology of Abdominal Aortic Aneurysms: Development of a Novel Rupture Mechanism Model

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