The role of calcium-binding proteins in the control of transcription: Structure to function

Mitsuhiko Ikura, Masanori Osawa, James B. Ames

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Transcriptional regulation is coupled with numerous intracellular signaling processes often mediated by second messengers. Now, growing evidence points to the importance of Ca2+, one of the most versatile second messengers, in activating or inhibiting gene transcription through actions frequently mediated by members of the EF-hand superfamily of Ca2+-binding proteins. Calmodulin and calcineurin, representative members of this EF-hand superfamily, indirectly regulate transcription through phosphorylation/dephosphorylation of transcription factors in response to a Ca2+ increase in the cell. Recently, a novel EF-hand Ca2+-binding protein called DREAM has been found to interact with regulatory sequences of DNA, thereby acting as a direct regulator of transcription. Finally, S100B, a dimeric EF-hand Ca2+ binding protein, interacts with the tumor suppressor p53 and controls its transcriptional activity. In light of the structural studies reported to date, this review provides an overview of the structural basis of EF-hand Ca2+ binding proteins linked with transcriptional regulation.

Original languageEnglish
Pages (from-to)625-636
Number of pages12
JournalBioEssays
Volume24
Issue number7
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

EF Hand Motifs
calcium-binding proteins
Calcium-Binding Proteins
Transcription
Carrier Proteins
transcription (genetics)
hands
calcium
binding proteins
Second Messenger Systems
second messengers
Phosphorylation
Calcineurin
Calmodulin
transcription factors
Tumors
regulatory sequences
Transcription Factors
dephosphorylation
Genes

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

The role of calcium-binding proteins in the control of transcription : Structure to function. / Ikura, Mitsuhiko; Osawa, Masanori; Ames, James B.

In: BioEssays, Vol. 24, No. 7, 2002, p. 625-636.

Research output: Contribution to journalArticle

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