The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding

Yusaku Takatori, Motohiko Kato, Yukie Sunata, Yuichiro Hirai, Yoko Kubosawa, Keichiro Abe, Yoshiaki Takada, Tetsu Hirata, Shigeo Banno, Michiko Wada, Satoshi Kinoshita, Hideki Mori, Kaoru Takabayashi, Miho Kikuchi, Masahiro Kikuchi, Masayuki Suzuki, Toshio Uraoka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. Aim: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. Methods: This is a retrospective cross-sectional study. Patients with UGIB admitted from April 2011 to August 2014 were included. The proportion of cases requiring EI and clinical factors (age, gender, antiplatelet/anticoagulant therapy, history of gastro-duodenal ulcer (GDU), systolic blood pressure, heart rate, hemoglobin, mean corpuscular volume, blood urea nitrogen-creatinine ratio (BUN/Cr ratio), prothrombin time-international normalized ratio, and Glasgow-Blatchford Score (GBS) were analyzed using logistic regression models. Result: Of 378 patients who were included in this study, 180 were found to be with GDU. The proportion of cases requiring EI was significantly higher in those with GDU than in other causes except variceal bleeding (53.5 vs. 37.0%, p < 0.01). Multivariate analysis revealed that a history of GDU was an independent risk factor (OR 1.78, 95% CI 1.06–3.00) in addition to BUN/Cr ratio (OR 1.02, 95% CI 1.00–1.03) and GBS (OR 1.19, 95% CI 1.08–1.33). Conclusion: A history of GDU was an independent risk factor for predicting the need for EI in UGIB in addition to BUN/Cr ratio and GBS.

Original languageEnglish
JournalDigestive Diseases
DOIs
Publication statusAccepted/In press - 2018 Jan 17
Externally publishedYes

Fingerprint

Duodenal Ulcer
Hemorrhage
Blood Urea Nitrogen
Creatinine
Logistic Models
Blood Pressure
Erythrocyte Indices
International Normalized Ratio
Age Factors
Prothrombin Time
Anticoagulants
Endoscopy
Hemoglobins
Emergencies
Multivariate Analysis
Cross-Sectional Studies
Heart Rate
Therapeutics

Keywords

  • Endoscopic intervention
  • Gastroduodenal ulcer
  • Risk factor
  • Upper gastrointestinal bleeding

ASJC Scopus subject areas

  • Gastroenterology

Cite this

The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. / Takatori, Yusaku; Kato, Motohiko; Sunata, Yukie; Hirai, Yuichiro; Kubosawa, Yoko; Abe, Keichiro; Takada, Yoshiaki; Hirata, Tetsu; Banno, Shigeo; Wada, Michiko; Kinoshita, Satoshi; Mori, Hideki; Takabayashi, Kaoru; Kikuchi, Miho; Kikuchi, Masahiro; Suzuki, Masayuki; Uraoka, Toshio.

In: Digestive Diseases, 17.01.2018.

Research output: Contribution to journalArticle

Takatori, Y, Kato, M, Sunata, Y, Hirai, Y, Kubosawa, Y, Abe, K, Takada, Y, Hirata, T, Banno, S, Wada, M, Kinoshita, S, Mori, H, Takabayashi, K, Kikuchi, M, Kikuchi, M, Suzuki, M & Uraoka, T 2018, 'The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding', Digestive Diseases. https://doi.org/10.1159/000486234
Takatori, Yusaku ; Kato, Motohiko ; Sunata, Yukie ; Hirai, Yuichiro ; Kubosawa, Yoko ; Abe, Keichiro ; Takada, Yoshiaki ; Hirata, Tetsu ; Banno, Shigeo ; Wada, Michiko ; Kinoshita, Satoshi ; Mori, Hideki ; Takabayashi, Kaoru ; Kikuchi, Miho ; Kikuchi, Masahiro ; Suzuki, Masayuki ; Uraoka, Toshio. / The Role of History of Gastro-Duodenal Ulcer in Patients with Upper Gastrointestinal Bleeding. In: Digestive Diseases. 2018.
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abstract = "Background: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. Aim: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. Methods: This is a retrospective cross-sectional study. Patients with UGIB admitted from April 2011 to August 2014 were included. The proportion of cases requiring EI and clinical factors (age, gender, antiplatelet/anticoagulant therapy, history of gastro-duodenal ulcer (GDU), systolic blood pressure, heart rate, hemoglobin, mean corpuscular volume, blood urea nitrogen-creatinine ratio (BUN/Cr ratio), prothrombin time-international normalized ratio, and Glasgow-Blatchford Score (GBS) were analyzed using logistic regression models. Result: Of 378 patients who were included in this study, 180 were found to be with GDU. The proportion of cases requiring EI was significantly higher in those with GDU than in other causes except variceal bleeding (53.5 vs. 37.0{\%}, p < 0.01). Multivariate analysis revealed that a history of GDU was an independent risk factor (OR 1.78, 95{\%} CI 1.06–3.00) in addition to BUN/Cr ratio (OR 1.02, 95{\%} CI 1.00–1.03) and GBS (OR 1.19, 95{\%} CI 1.08–1.33). Conclusion: A history of GDU was an independent risk factor for predicting the need for EI in UGIB in addition to BUN/Cr ratio and GBS.",
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author = "Yusaku Takatori and Motohiko Kato and Yukie Sunata and Yuichiro Hirai and Yoko Kubosawa and Keichiro Abe and Yoshiaki Takada and Tetsu Hirata and Shigeo Banno and Michiko Wada and Satoshi Kinoshita and Hideki Mori and Kaoru Takabayashi and Miho Kikuchi and Masahiro Kikuchi and Masayuki Suzuki and Toshio Uraoka",
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AU - Takatori, Yusaku

AU - Kato, Motohiko

AU - Sunata, Yukie

AU - Hirai, Yuichiro

AU - Kubosawa, Yoko

AU - Abe, Keichiro

AU - Takada, Yoshiaki

AU - Hirata, Tetsu

AU - Banno, Shigeo

AU - Wada, Michiko

AU - Kinoshita, Satoshi

AU - Mori, Hideki

AU - Takabayashi, Kaoru

AU - Kikuchi, Miho

AU - Kikuchi, Masahiro

AU - Suzuki, Masayuki

AU - Uraoka, Toshio

PY - 2018/1/17

Y1 - 2018/1/17

N2 - Background: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. Aim: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. Methods: This is a retrospective cross-sectional study. Patients with UGIB admitted from April 2011 to August 2014 were included. The proportion of cases requiring EI and clinical factors (age, gender, antiplatelet/anticoagulant therapy, history of gastro-duodenal ulcer (GDU), systolic blood pressure, heart rate, hemoglobin, mean corpuscular volume, blood urea nitrogen-creatinine ratio (BUN/Cr ratio), prothrombin time-international normalized ratio, and Glasgow-Blatchford Score (GBS) were analyzed using logistic regression models. Result: Of 378 patients who were included in this study, 180 were found to be with GDU. The proportion of cases requiring EI was significantly higher in those with GDU than in other causes except variceal bleeding (53.5 vs. 37.0%, p < 0.01). Multivariate analysis revealed that a history of GDU was an independent risk factor (OR 1.78, 95% CI 1.06–3.00) in addition to BUN/Cr ratio (OR 1.02, 95% CI 1.00–1.03) and GBS (OR 1.19, 95% CI 1.08–1.33). Conclusion: A history of GDU was an independent risk factor for predicting the need for EI in UGIB in addition to BUN/Cr ratio and GBS.

AB - Background: Some scoring systems have been introduced to predict the need for performing urgent endoscopy in patients with upper gastrointestinal bleeding (UGIB). However, in an emergency situation, this intervention is insufficient and cannot easily provide the required treatment. Aim: To identify new risk factors that can predict the need for endoscopic intervention (EI) in UGIB patients. Methods: This is a retrospective cross-sectional study. Patients with UGIB admitted from April 2011 to August 2014 were included. The proportion of cases requiring EI and clinical factors (age, gender, antiplatelet/anticoagulant therapy, history of gastro-duodenal ulcer (GDU), systolic blood pressure, heart rate, hemoglobin, mean corpuscular volume, blood urea nitrogen-creatinine ratio (BUN/Cr ratio), prothrombin time-international normalized ratio, and Glasgow-Blatchford Score (GBS) were analyzed using logistic regression models. Result: Of 378 patients who were included in this study, 180 were found to be with GDU. The proportion of cases requiring EI was significantly higher in those with GDU than in other causes except variceal bleeding (53.5 vs. 37.0%, p < 0.01). Multivariate analysis revealed that a history of GDU was an independent risk factor (OR 1.78, 95% CI 1.06–3.00) in addition to BUN/Cr ratio (OR 1.02, 95% CI 1.00–1.03) and GBS (OR 1.19, 95% CI 1.08–1.33). Conclusion: A history of GDU was an independent risk factor for predicting the need for EI in UGIB in addition to BUN/Cr ratio and GBS.

KW - Endoscopic intervention

KW - Gastroduodenal ulcer

KW - Risk factor

KW - Upper gastrointestinal bleeding

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