TY - JOUR
T1 - The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches
AU - Iiyama, R.
AU - Kanai, T.
AU - Uraushihara, K.
AU - Totsuka, T.
AU - Nakamura, T.
AU - Miyata, T.
AU - Yagita, H.
AU - Kushi, A.
AU - Suzuki, K.
AU - Tezuka, K.
AU - Watanabe, M.
PY - 2003/7/3
Y1 - 2003/7/3
N2 - T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.
AB - T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.
KW - Development
KW - Germinal center
KW - ICOS
KW - IgA
KW - Peyer's patch
UR - http://www.scopus.com/inward/record.url?scp=10744223294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10744223294&partnerID=8YFLogxK
U2 - 10.1016/S0165-2478(03)00054-3
DO - 10.1016/S0165-2478(03)00054-3
M3 - Article
C2 - 12853164
AN - SCOPUS:10744223294
VL - 88
SP - 63
EP - 70
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 1
ER -