The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches

R. Iiyama, T. Kanai, K. Uraushihara, T. Totsuka, T. Nakamura, T. Miyata, H. Yagita, A. Kushi, K. Suzuki, K. Tezuka, M. Watanabe

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10 Citations (Scopus)

Abstract

T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalImmunology Letters
Volume88
Issue number1
DOIs
Publication statusPublished - 2003 Jul 3
Externally publishedYes

Keywords

  • Development
  • Germinal center
  • ICOS
  • IgA
  • Peyer's patch

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Iiyama, R., Kanai, T., Uraushihara, K., Totsuka, T., Nakamura, T., Miyata, T., Yagita, H., Kushi, A., Suzuki, K., Tezuka, K., & Watanabe, M. (2003). The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. Immunology Letters, 88(1), 63-70. https://doi.org/10.1016/S0165-2478(03)00054-3