The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches

R. Iiyama, T. Kanai, K. Uraushihara, T. Totsuka, T. Nakamura, T. Miyata, H. Yagita, A. Kushi, K. Suzuki, K. Tezuka, M. Watanabe

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalImmunology Letters
Volume88
Issue number1
DOIs
Publication statusPublished - 2003 Jul 3
Externally publishedYes

Keywords

  • Development
  • Germinal center
  • ICOS
  • IgA
  • Peyer's patch

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches'. Together they form a unique fingerprint.

Cite this