The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches

R. Iiyama, Takanori Kanai, K. Uraushihara, T. Totsuka, T. Nakamura, T. Miyata, H. Yagita, A. Kushi, K. Suzuki, K. Tezuka, M. Watanabe

Research output: Contribution to journalArticle

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Abstract

T-cell co-stimulatory molecule, inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interactions play an essential role of T-cell-dependent B-cell activation in peripheral lymphoid organs such as spleen and lymph nodes. Here, we investigate the role of ICOS/B7RP-1 interactions in the development of Peyer's patches (PPs). In ICOS-/- mice, the number of PPs was not decreased, although PPs in ICOS-/- mice were significantly reduced in size. Phenotypic analysis showed no obvious differences between ICOS-/- and ICOS+/- mice in the distribution of T-cells, B-cells, macrophages and dendritic cells. However, PNA+ cells characteristic of intestinal germinal centers were totally absent in ICOS-/- mice. Moreover, production of IgA and IgG, but not IgM was significantly reduced in PPs in ICOS-/- mice. These data suggest that ICOS/B7RP-1 interactions may not affect the organogenesis, but involve in the functional development of PPs.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalImmunology Letters
Volume88
Issue number1
DOIs
Publication statusPublished - 2003 Jul 3
Externally publishedYes

Fingerprint

Inducible T-Cell Co-Stimulator Ligand
Inducible T-Cell Co-Stimulator Protein
Peyer's Patches
T-Lymphocytes
B-Lymphocytes
Germinal Center
Organogenesis
Dendritic Cells
Immunoglobulin A

Keywords

  • Development
  • Germinal center
  • ICOS
  • IgA
  • Peyer's patch

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. / Iiyama, R.; Kanai, Takanori; Uraushihara, K.; Totsuka, T.; Nakamura, T.; Miyata, T.; Yagita, H.; Kushi, A.; Suzuki, K.; Tezuka, K.; Watanabe, M.

In: Immunology Letters, Vol. 88, No. 1, 03.07.2003, p. 63-70.

Research output: Contribution to journalArticle

Iiyama, R, Kanai, T, Uraushihara, K, Totsuka, T, Nakamura, T, Miyata, T, Yagita, H, Kushi, A, Suzuki, K, Tezuka, K & Watanabe, M 2003, 'The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches', Immunology Letters, vol. 88, no. 1, pp. 63-70. https://doi.org/10.1016/S0165-2478(03)00054-3
Iiyama, R. ; Kanai, Takanori ; Uraushihara, K. ; Totsuka, T. ; Nakamura, T. ; Miyata, T. ; Yagita, H. ; Kushi, A. ; Suzuki, K. ; Tezuka, K. ; Watanabe, M. / The role of inducible co-stimulator (ICOS)/B7-related protein-1 (B7RP-1) interaction in the functional development of Peyer's patches. In: Immunology Letters. 2003 ; Vol. 88, No. 1. pp. 63-70.
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