The role of matrix metalloproteinases in glioma invasion

Mitsutoshi Nakada, Yasunori Okada, Junkoh Yamashita

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated MMP levels and tumor cell invasiveness in human gliomas. Among them, attention has been focused on gelatinases (MMP-2 and MMP-9) and membrane type MMPs (MT-MMPs). We discuss here the biological significance of these MMPs in the glioblastoma invasion processes. A better understanding of cell-ECM interactions will help in developing therapeutic strategies to decrease the invasion of gliomas.

Original languageEnglish
JournalFrontiers in Bioscience
Volume8
Publication statusPublished - 2003

Fingerprint

Matrix Metalloproteinases
Glioma
Extracellular Matrix
Cells
Degradation
Gelatinases
Matrix Metalloproteinase 2
Matrix Metalloproteinase 9
Glioblastoma
Tumors
Neoplasms
Tissue
Neoplasm Metastasis
Membranes
Therapeutics

Keywords

  • Brain
  • Cancer
  • Glioma
  • Invasion
  • Matrix Metalloproteinase
  • Nervous system
  • Review
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Nakada, M., Okada, Y., & Yamashita, J. (2003). The role of matrix metalloproteinases in glioma invasion. Frontiers in Bioscience, 8.

The role of matrix metalloproteinases in glioma invasion. / Nakada, Mitsutoshi; Okada, Yasunori; Yamashita, Junkoh.

In: Frontiers in Bioscience, Vol. 8, 2003.

Research output: Contribution to journalArticle

Nakada, M, Okada, Y & Yamashita, J 2003, 'The role of matrix metalloproteinases in glioma invasion', Frontiers in Bioscience, vol. 8.
Nakada, Mitsutoshi ; Okada, Yasunori ; Yamashita, Junkoh. / The role of matrix metalloproteinases in glioma invasion. In: Frontiers in Bioscience. 2003 ; Vol. 8.
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