The role of microRNA in gastric malignancy

Toshihiro Nishizawa, Hidekazu Suzuki

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.

Original languageEnglish
Pages (from-to)9487-9496
Number of pages10
JournalInternational journal of molecular sciences
Volume14
Issue number5
DOIs
Publication statusPublished - 2013 May

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • MicroRNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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