The role of microRNA in gastric malignancy

Toshihiro Nishizawa, Hidekazu Suzuki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Helicobacter pylori (H. pylori) infection is the main cause of gastritis, gastro-duodenal ulcer, and gastric cancer. MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Many miRNA genes are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Recent discoveries have shed new light on the involvement of miRNAs in gastric malignancy. However, at the same time, several miRNAs have been associated with opposing events, leading to reduced inflammation, inhibition of malignancy, and increased apoptosis of transformed cells. The regulation of miRNA expression could be a novel strategy in the chemoprevention of human gastric malignancy. In this article, the biological importance of miRNAs in gastric malignancy is summarized.

Original languageEnglish
Pages (from-to)9487-9496
Number of pages10
JournalInternational Journal of Molecular Sciences
Volume14
Issue number5
DOIs
Publication statusPublished - 2013 May

Fingerprint

apoptosis
Cell death
MicroRNAs
genes
Stomach
Genes
silencers
ulcers
Cell proliferation
infectious diseases
RNA
Neoplasms
cancer
Tissue
causes
Duodenal Neoplasms
cells
Apoptosis
Small Untranslated RNA
Chemoprevention

Keywords

  • Gastric cancer
  • Helicobacter pylori
  • MicroRNA

ASJC Scopus subject areas

  • Computer Science Applications
  • Molecular Biology
  • Catalysis
  • Inorganic Chemistry
  • Spectroscopy
  • Organic Chemistry
  • Physical and Theoretical Chemistry

Cite this

The role of microRNA in gastric malignancy. / Nishizawa, Toshihiro; Suzuki, Hidekazu.

In: International Journal of Molecular Sciences, Vol. 14, No. 5, 05.2013, p. 9487-9496.

Research output: Contribution to journalArticle

Nishizawa, Toshihiro ; Suzuki, Hidekazu. / The role of microRNA in gastric malignancy. In: International Journal of Molecular Sciences. 2013 ; Vol. 14, No. 5. pp. 9487-9496.
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