Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Hundreds of human miRNAs have been identified in the human genome, and they are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Links between miRNAs and human diseases are increasingly apparent, and aberrant expression of miRNAs may contribute to the development and progression of human malignancies. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in gastrointestinal cancers. miRNA expression is regulated by different mechanisms including transcription factor binding, epigenetic alterations, and chromosomal abnormalities. miRNA expression profiling may be a powerful clinical tool for cancer diagnosis, and regulation of miRNA expression could be a novel strategy for the chemoprevention of human gastrointestinal cancers. In this article, the biological importance of miRNAs in human gastrointestinal cancers is summarized.
| Original language | English |
|---|---|
| Pages (from-to) | 18-22 |
| Number of pages | 5 |
| Journal | Journal of Gastroenterology |
| Volume | 44 |
| Issue number | SUPPL. 19 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Cyclooxygenase (COX)
- Epigenetics
- Gastrointestinal cancer
- Helicobacter pylori
- MicroRNA
ASJC Scopus subject areas
- Gastroenterology
Cite this
The role of microRNAs in gastrointestinal cancers. / Saito, Yoshimasa; Suzuki, Hidekazu; Hibi, Toshifumi.
In: Journal of Gastroenterology, Vol. 44, No. SUPPL. 19, 2009, p. 18-22.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of microRNAs in gastrointestinal cancers
AU - Saito, Yoshimasa
AU - Suzuki, Hidekazu
AU - Hibi, Toshifumi
PY - 2009
Y1 - 2009
N2 - MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Hundreds of human miRNAs have been identified in the human genome, and they are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Links between miRNAs and human diseases are increasingly apparent, and aberrant expression of miRNAs may contribute to the development and progression of human malignancies. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in gastrointestinal cancers. miRNA expression is regulated by different mechanisms including transcription factor binding, epigenetic alterations, and chromosomal abnormalities. miRNA expression profiling may be a powerful clinical tool for cancer diagnosis, and regulation of miRNA expression could be a novel strategy for the chemoprevention of human gastrointestinal cancers. In this article, the biological importance of miRNAs in human gastrointestinal cancers is summarized.
AB - MicroRNAs (miRNAs) are small noncoding RNAs that function as endogenous silencers of numerous target genes. Hundreds of human miRNAs have been identified in the human genome, and they are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Links between miRNAs and human diseases are increasingly apparent, and aberrant expression of miRNAs may contribute to the development and progression of human malignancies. Recent studies have shown that some miRNAs play roles as tumor suppressors or oncogenes in gastrointestinal cancers. miRNA expression is regulated by different mechanisms including transcription factor binding, epigenetic alterations, and chromosomal abnormalities. miRNA expression profiling may be a powerful clinical tool for cancer diagnosis, and regulation of miRNA expression could be a novel strategy for the chemoprevention of human gastrointestinal cancers. In this article, the biological importance of miRNAs in human gastrointestinal cancers is summarized.
KW - Cyclooxygenase (COX)
KW - Epigenetics
KW - Gastrointestinal cancer
KW - Helicobacter pylori
KW - MicroRNA
UR - http://www.scopus.com/inward/record.url?scp=58849131081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58849131081&partnerID=8YFLogxK
U2 - 10.1007/s00535-008-2285-3
DO - 10.1007/s00535-008-2285-3
M3 - Article
C2 - 19148788
AN - SCOPUS:58849131081
VL - 44
SP - 18
EP - 22
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - SUPPL. 19
ER -