Abstract
There is a growing body of evidence to suggest that oxidative stress may be involved in at least the propagation of cellular injury that leads to eye pathology in various conditions including conjunctivochalasis, dry eye disease, age-related macular degeneration, and UV light-induced and tobacco smoke-induced ocular surface epithelial damage. Oxidative stress is biologically relevant in vivo and intimately linked with an integrated series of cellular events. Interaction between these various components is not necessarily a cascade but might be a cycle of events, of which oxidative stress is a major component. Inhibition of oxidative stress therapeutically might act to "break the cycle" of cell death. The creation of numerous cell and animal models that selectively target the effects of oxidative stress and inflammation to the specifically affected eye region in these diseases has greatly advanced our understanding of the involvement of oxidative stress in eye disease.
| Original language | English |
|---|---|
| Journal | Cornea |
| Volume | 28 |
| Issue number | SUPPL. 1 |
| DOIs | |
| Publication status | Published - 2009 |
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Keywords
- Cytokines
- Dry eye
- Inflammation
- Oxidative stress
ASJC Scopus subject areas
- Ophthalmology
Cite this
The role of oxidative stress and inflammation in dry eye disease. / Dogru, Murat; Wakamatsu, Tais; Kojima, Takashi; Matsumoto, Yukihiro; Kawakita, Tetsuya; Schnider, Christina; Tsubota, Kazuo.
In: Cornea, Vol. 28, No. SUPPL. 1, 2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of oxidative stress and inflammation in dry eye disease
AU - Dogru, Murat
AU - Wakamatsu, Tais
AU - Kojima, Takashi
AU - Matsumoto, Yukihiro
AU - Kawakita, Tetsuya
AU - Schnider, Christina
AU - Tsubota, Kazuo
PY - 2009
Y1 - 2009
N2 - There is a growing body of evidence to suggest that oxidative stress may be involved in at least the propagation of cellular injury that leads to eye pathology in various conditions including conjunctivochalasis, dry eye disease, age-related macular degeneration, and UV light-induced and tobacco smoke-induced ocular surface epithelial damage. Oxidative stress is biologically relevant in vivo and intimately linked with an integrated series of cellular events. Interaction between these various components is not necessarily a cascade but might be a cycle of events, of which oxidative stress is a major component. Inhibition of oxidative stress therapeutically might act to "break the cycle" of cell death. The creation of numerous cell and animal models that selectively target the effects of oxidative stress and inflammation to the specifically affected eye region in these diseases has greatly advanced our understanding of the involvement of oxidative stress in eye disease.
AB - There is a growing body of evidence to suggest that oxidative stress may be involved in at least the propagation of cellular injury that leads to eye pathology in various conditions including conjunctivochalasis, dry eye disease, age-related macular degeneration, and UV light-induced and tobacco smoke-induced ocular surface epithelial damage. Oxidative stress is biologically relevant in vivo and intimately linked with an integrated series of cellular events. Interaction between these various components is not necessarily a cascade but might be a cycle of events, of which oxidative stress is a major component. Inhibition of oxidative stress therapeutically might act to "break the cycle" of cell death. The creation of numerous cell and animal models that selectively target the effects of oxidative stress and inflammation to the specifically affected eye region in these diseases has greatly advanced our understanding of the involvement of oxidative stress in eye disease.
KW - Cytokines
KW - Dry eye
KW - Inflammation
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=76449086507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=76449086507&partnerID=8YFLogxK
U2 - 10.1097/ICO.0b013e3181ae8689
DO - 10.1097/ICO.0b013e3181ae8689
M3 - Article
VL - 28
JO - Cornea
JF - Cornea
SN - 0277-3740
IS - SUPPL. 1
ER -