The role of p53 mutation in the carcinomas arising from endometriosis

Tomoko Akahane, Akihiko Sekizawa, Yuditiya Purwosunu, Masaaki Nagatsuka, Takashi Okai

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

To probe the mechanism of the development of ovarian cancer from endometriosis, which is a multistep process that involves the activation of oncogenes and inactivation of tumor suppressor genes, we evaluated p53 mutations in solitary endometriosis and endometriosis coexisting with ovarian clear cell carcinoma (OCCA) and ovarian endometrioid carcinoma (OEC). We examined 7 cases of solitary ovarian endometriosis, 13 cases of OCCA, and 9 cases of OEC. Cancer tissue specimens that also contained endometriosis without atypia were chosen. Using a laser microdissection system, epithelial cells from the areas of endometriosis were isolated, and DNA was extracted. We amplified exons 5, 6, 7, and 8 of the p53 gene, and direct sequencing was performed. p53 mutation was observed in 4 (30.8%) of 13 specimens of endometriosis coexisting with OCCA, whereas no mutations were detected in solitary endometriosis or endometriosis coexisting with OEC. We thought that some genetic alterations, which induce p53 mutations in endometriosis, may affect malignant transformation of endometriosis into OCCA.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume26
Issue number3
DOIs
Publication statusPublished - 2007 Jul 1

Keywords

  • Carcinogenesis
  • Endometriosis
  • Ovarian clear cell carcinoma
  • Ovarian endometrial carcinoma
  • p53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynaecology

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