The role of pit-1 in the regulation of the rat growth hormone-releasing hormone receptor transcription by glucocorticoids

Haruo Nogami, Yoshiki Hiraoka, Kiyomoto Ogasawara, Sadakazu Aiso, Setsuji Hisano

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Glucocorticoids are involved in the regulation of the rat growth hormone-releasing hormone (GHRH) receptor gene expression, but they act only in the presence of the pituitary specific transcription factor, pit-1. In this study, the role of pit-1 in the glucocorticoid stimulation of the GHRH-receptor gene transcription was examined. The results suggest the presence of a silencer element in the promoter and it is postulated that pit-1 permits glucocorticoid action through suppressing the inhibitory effect of an as yet unknown factor that binds to this element. The present results also suggest that the synergistic activation of the rat GHRH-receptor gene transcription depends on the proper distance between the proximal glucocorticoid response element and the pit-1 binding site.

Original languageEnglish
Pages (from-to)477-488
Number of pages12
JournalJournal of Molecular Endocrinology
Volume35
Issue number3
DOIs
Publication statusPublished - 2005 Dec 1

ASJC Scopus subject areas

  • Molecular Biology
  • Endocrinology

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