The role of the clathrin adaptor AP-1: Polarized sorting and beyond

Fubito Nakatsu, Koji Hase, Hiroshi Ohno

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

The selective transport of proteins or lipids by vesicular transport is a fundamental process supporting cellular physiology. The budding process involves cargo sorting and vesicle formation at the donor membrane and constitutes an important process in vesicular transport. This process is particularly important for the polarized sorting in epithelial cells, in which the cargo molecules need to be selectively sorted and transported to two distinct destinations, the apical or basolateral plasma membrane. Adaptor protein (AP)-1, a member of the AP complex family, which includes the ubiquitously expressed AP-1A and the epithelium-specific AP-1B, regulates polarized sorting at the trans-Golgi network and/or at the recycling endosomes. A growing body of evidence, especially from studies using model organisms and animals, demonstrates that the AP-1-mediated polarized sorting supports the development and physiology of multi-cellular units as functional organs and tissues (e.g., cell fate determination, inflammation and gut immune homeostasis). Furthermore, a possible involvement of AP-1B in the pathogenesis of human diseases, such as Crohn’s disease and cancer, is now becoming evident. These data highlight the significant contribution of AP-1 complexes to the physiology of multicellular organisms, as master regulators of polarized sorting in epithelial cells.

Original languageEnglish
Pages (from-to)747-763
Number of pages17
JournalMembranes
Volume4
Issue number4
DOIs
Publication statusPublished - 2014 Nov 7

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Keywords

  • AP complex
  • Cancer
  • Clathrin adaptor
  • Epithelial cell
  • Inflammation
  • Polarized sorting
  • Sorting signal
  • Vesicular transport
  • μ1B

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology
  • Filtration and Separation

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