The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts

Tomàs Pinós, Noriyuki Fuku, Yolanda Cámara, Yasumichi Arai, Yukiko Abe, Gabriel Rodríguez-Romo, Nuria Garatachea, Alejandro Santos-Lozano, Elisabet Miro-Casas, Marisol Ruiz-Meana, Imanol Otaegui, Haruka Murakami, Motohiko Miyachi, David Garcia-Dorado, Kunihiko Hinohara, Antoni L. Andreu, Akinori Kimura, Nobuyoshi Hirose, Alejandro Lucia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n∈=∈152, 128 women, 100-111 years; healthy controls: n∈=∈343, 212 women, age <50 years; CAD controls: n∈=∈98, 32 women, age 65 years) and Japanese (centenarians: n∈=∈742, 623 women, 100-115 years; healthy controls: n∈=∈920, 511 women, 60 years; CAD controls: n∈=∈395, 45 women, age 65 years). The frequency of the "risk" C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P∈=∈0.088) or CAD controls (55.1 %, P∈=∈0.078), and significant differences were found in genotype distributions (P∈=∈0.034 and P∈=∈0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P∈=∈0.602) , but it was significantly lower in the former than in CAD controls (57.2 %, P∈<∈0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.

Original languageEnglish
Pages (from-to)933-943
Number of pages11
JournalAge
Volume36
Issue number2
DOIs
Publication statusPublished - 2014

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Coronary Artery Disease
Genotype
Alleles
Rejuvenation
Gene Frequency
Population
Young Adult
Chromosomes
Research

Keywords

  • CDKN2A
  • CDKN2B
  • Centenarians
  • Coronary artery disease
  • Genetics

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Pinós, T., Fuku, N., Cámara, Y., Arai, Y., Abe, Y., Rodríguez-Romo, G., ... Lucia, A. (2014). The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. Age, 36(2), 933-943. https://doi.org/10.1007/s11357-013-9593-0

The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. / Pinós, Tomàs; Fuku, Noriyuki; Cámara, Yolanda; Arai, Yasumichi; Abe, Yukiko; Rodríguez-Romo, Gabriel; Garatachea, Nuria; Santos-Lozano, Alejandro; Miro-Casas, Elisabet; Ruiz-Meana, Marisol; Otaegui, Imanol; Murakami, Haruka; Miyachi, Motohiko; Garcia-Dorado, David; Hinohara, Kunihiko; Andreu, Antoni L.; Kimura, Akinori; Hirose, Nobuyoshi; Lucia, Alejandro.

In: Age, Vol. 36, No. 2, 2014, p. 933-943.

Research output: Contribution to journalArticle

Pinós, T, Fuku, N, Cámara, Y, Arai, Y, Abe, Y, Rodríguez-Romo, G, Garatachea, N, Santos-Lozano, A, Miro-Casas, E, Ruiz-Meana, M, Otaegui, I, Murakami, H, Miyachi, M, Garcia-Dorado, D, Hinohara, K, Andreu, AL, Kimura, A, Hirose, N & Lucia, A 2014, 'The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts', Age, vol. 36, no. 2, pp. 933-943. https://doi.org/10.1007/s11357-013-9593-0
Pinós, Tomàs ; Fuku, Noriyuki ; Cámara, Yolanda ; Arai, Yasumichi ; Abe, Yukiko ; Rodríguez-Romo, Gabriel ; Garatachea, Nuria ; Santos-Lozano, Alejandro ; Miro-Casas, Elisabet ; Ruiz-Meana, Marisol ; Otaegui, Imanol ; Murakami, Haruka ; Miyachi, Motohiko ; Garcia-Dorado, David ; Hinohara, Kunihiko ; Andreu, Antoni L. ; Kimura, Akinori ; Hirose, Nobuyoshi ; Lucia, Alejandro. / The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts. In: Age. 2014 ; Vol. 36, No. 2. pp. 933-943.
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AU - Pinós, Tomàs

AU - Fuku, Noriyuki

AU - Cámara, Yolanda

AU - Arai, Yasumichi

AU - Abe, Yukiko

AU - Rodríguez-Romo, Gabriel

AU - Garatachea, Nuria

AU - Santos-Lozano, Alejandro

AU - Miro-Casas, Elisabet

AU - Ruiz-Meana, Marisol

AU - Otaegui, Imanol

AU - Murakami, Haruka

AU - Miyachi, Motohiko

AU - Garcia-Dorado, David

AU - Hinohara, Kunihiko

AU - Andreu, Antoni L.

AU - Kimura, Akinori

AU - Hirose, Nobuyoshi

AU - Lucia, Alejandro

PY - 2014

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N2 - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n∈=∈152, 128 women, 100-111 years; healthy controls: n∈=∈343, 212 women, age <50 years; CAD controls: n∈=∈98, 32 women, age 65 years) and Japanese (centenarians: n∈=∈742, 623 women, 100-115 years; healthy controls: n∈=∈920, 511 women, 60 years; CAD controls: n∈=∈395, 45 women, age 65 years). The frequency of the "risk" C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P∈=∈0.088) or CAD controls (55.1 %, P∈=∈0.078), and significant differences were found in genotype distributions (P∈=∈0.034 and P∈=∈0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P∈=∈0.602) , but it was significantly lower in the former than in CAD controls (57.2 %, P∈<∈0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.

AB - The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n∈=∈152, 128 women, 100-111 years; healthy controls: n∈=∈343, 212 women, age <50 years; CAD controls: n∈=∈98, 32 women, age 65 years) and Japanese (centenarians: n∈=∈742, 623 women, 100-115 years; healthy controls: n∈=∈920, 511 women, 60 years; CAD controls: n∈=∈395, 45 women, age 65 years). The frequency of the "risk" C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P∈=∈0.088) or CAD controls (55.1 %, P∈=∈0.078), and significant differences were found in genotype distributions (P∈=∈0.034 and P∈=∈0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P∈=∈0.602) , but it was significantly lower in the former than in CAD controls (57.2 %, P∈<∈0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23-26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.

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