The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013

Ryoichi Hamasuna, Mitsuru Yasuda, Kiyohito Ishikawa, Shinya Uehara, Hiroshi Hayami, Satoshi Takahashi, Tetsuro Matsumoto, Shingo Yamamoto, Shinichi Minamitani, Akira Watanabe, Satoshi Iwata, Mitsuo Kaku, Junichi Kadota, Keisuke Sunakawa, Junko Sato, Hideaki Hanaki, Taiji Tsukamoto, Hiroshi Kiyota, Shin Egawa, Kazushi Tanaka & 33 others Soichi Arakawa, Masato Fujisawa, Hiromi Kumon, Kanao Kobayashi, Akio Matsubara, Seiji Naito, Kentaro Kuroiwa, Hideo Hirayama, Harunori Narita, Takahide Hosobe, Shin Ito, Kenji Ito, Shuichi Kawai, Masayasu Ito, Hirofumi Chokyu, Masaru Matsumura, Masaru Yoshioka, Satoshi Uno, Koichi Monden, Kazuo Takayama, Shinichi Kaji, Motoshi Kawahara, Toru Sumii, Hitoshi Kadena, Takamasa Yamaguchi, Shinichi Maeda, Shohei Nishi, Hirofumi Nishimura, Takeshi Shirane, Mutsumasa Yoh, Kikuo Akiyama, Toshio Imai, Motonori Kano

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N.gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study. Urethral discharge was collected from male patients with urethritis at 26 medical facilities from March 2012 to January 2013. Of the 151 specimens, 103 N.gonorrhoeae strains were tested for susceptibility to 20 antimicrobial agents. None of the strains was resistant to ceftriaxone, but the minimum inhibitory concentration (MIC) 90% of ceftriaxone increased to 0.125 μg/ml, and 11 (10.7%) strains were considered less susceptible with an MIC of 0.125 μg/ml. There were 11 strains resistant to cefixime, and the MICs of these strains were 0.5μg/ml. The distributions of the MICs of fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin, were bimodal. Sitafloxacin, a fluoroquinolone, showed strong activity against all strains, including strains resistant to other three fluoroquinolones, such as ciprofloxacin, levofloxacin and tosufloxacin. The azithromycin MICs in 2 strains were 1μg/ml.

Original languageEnglish
Pages (from-to)340-345
Number of pages6
JournalJournal of Infection and Chemotherapy
Volume21
Issue number5
DOIs
Publication statusPublished - 2015
Externally publishedYes

Fingerprint

Urethritis
Neisseria gonorrhoeae
Fluoroquinolones
tosufloxacin
Japan
Levofloxacin
Ceftriaxone
Gonorrhea
Microbial Sensitivity Tests
Ciprofloxacin
Cephalosporin Resistance
Cefixime
Azithromycin
Macrolides
Sexually Transmitted Diseases
Anti-Infective Agents
Penicillins
Therapeutics

Keywords

  • 2012
  • 2013
  • Antimicrobial susceptibilities
  • Japan
  • Nationwide surveillance
  • Neisseria gonorrhoeae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013. / Hamasuna, Ryoichi; Yasuda, Mitsuru; Ishikawa, Kiyohito; Uehara, Shinya; Hayami, Hiroshi; Takahashi, Satoshi; Matsumoto, Tetsuro; Yamamoto, Shingo; Minamitani, Shinichi; Watanabe, Akira; Iwata, Satoshi; Kaku, Mitsuo; Kadota, Junichi; Sunakawa, Keisuke; Sato, Junko; Hanaki, Hideaki; Tsukamoto, Taiji; Kiyota, Hiroshi; Egawa, Shin; Tanaka, Kazushi; Arakawa, Soichi; Fujisawa, Masato; Kumon, Hiromi; Kobayashi, Kanao; Matsubara, Akio; Naito, Seiji; Kuroiwa, Kentaro; Hirayama, Hideo; Narita, Harunori; Hosobe, Takahide; Ito, Shin; Ito, Kenji; Kawai, Shuichi; Ito, Masayasu; Chokyu, Hirofumi; Matsumura, Masaru; Yoshioka, Masaru; Uno, Satoshi; Monden, Koichi; Takayama, Kazuo; Kaji, Shinichi; Kawahara, Motoshi; Sumii, Toru; Kadena, Hitoshi; Yamaguchi, Takamasa; Maeda, Shinichi; Nishi, Shohei; Nishimura, Hirofumi; Shirane, Takeshi; Yoh, Mutsumasa; Akiyama, Kikuo; Imai, Toshio; Kano, Motonori.

In: Journal of Infection and Chemotherapy, Vol. 21, No. 5, 2015, p. 340-345.

Research output: Contribution to journalArticle

Hamasuna, R, Yasuda, M, Ishikawa, K, Uehara, S, Hayami, H, Takahashi, S, Matsumoto, T, Yamamoto, S, Minamitani, S, Watanabe, A, Iwata, S, Kaku, M, Kadota, J, Sunakawa, K, Sato, J, Hanaki, H, Tsukamoto, T, Kiyota, H, Egawa, S, Tanaka, K, Arakawa, S, Fujisawa, M, Kumon, H, Kobayashi, K, Matsubara, A, Naito, S, Kuroiwa, K, Hirayama, H, Narita, H, Hosobe, T, Ito, S, Ito, K, Kawai, S, Ito, M, Chokyu, H, Matsumura, M, Yoshioka, M, Uno, S, Monden, K, Takayama, K, Kaji, S, Kawahara, M, Sumii, T, Kadena, H, Yamaguchi, T, Maeda, S, Nishi, S, Nishimura, H, Shirane, T, Yoh, M, Akiyama, K, Imai, T & Kano, M 2015, 'The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013', Journal of Infection and Chemotherapy, vol. 21, no. 5, pp. 340-345. https://doi.org/10.1016/j.jiac.2015.01.010
Hamasuna, Ryoichi ; Yasuda, Mitsuru ; Ishikawa, Kiyohito ; Uehara, Shinya ; Hayami, Hiroshi ; Takahashi, Satoshi ; Matsumoto, Tetsuro ; Yamamoto, Shingo ; Minamitani, Shinichi ; Watanabe, Akira ; Iwata, Satoshi ; Kaku, Mitsuo ; Kadota, Junichi ; Sunakawa, Keisuke ; Sato, Junko ; Hanaki, Hideaki ; Tsukamoto, Taiji ; Kiyota, Hiroshi ; Egawa, Shin ; Tanaka, Kazushi ; Arakawa, Soichi ; Fujisawa, Masato ; Kumon, Hiromi ; Kobayashi, Kanao ; Matsubara, Akio ; Naito, Seiji ; Kuroiwa, Kentaro ; Hirayama, Hideo ; Narita, Harunori ; Hosobe, Takahide ; Ito, Shin ; Ito, Kenji ; Kawai, Shuichi ; Ito, Masayasu ; Chokyu, Hirofumi ; Matsumura, Masaru ; Yoshioka, Masaru ; Uno, Satoshi ; Monden, Koichi ; Takayama, Kazuo ; Kaji, Shinichi ; Kawahara, Motoshi ; Sumii, Toru ; Kadena, Hitoshi ; Yamaguchi, Takamasa ; Maeda, Shinichi ; Nishi, Shohei ; Nishimura, Hirofumi ; Shirane, Takeshi ; Yoh, Mutsumasa ; Akiyama, Kikuo ; Imai, Toshio ; Kano, Motonori. / The second nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan, 2012-2013. In: Journal of Infection and Chemotherapy. 2015 ; Vol. 21, No. 5. pp. 340-345.
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AU - Uehara, Shinya

AU - Hayami, Hiroshi

AU - Takahashi, Satoshi

AU - Matsumoto, Tetsuro

AU - Yamamoto, Shingo

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AU - Egawa, Shin

AU - Tanaka, Kazushi

AU - Arakawa, Soichi

AU - Fujisawa, Masato

AU - Kumon, Hiromi

AU - Kobayashi, Kanao

AU - Matsubara, Akio

AU - Naito, Seiji

AU - Kuroiwa, Kentaro

AU - Hirayama, Hideo

AU - Narita, Harunori

AU - Hosobe, Takahide

AU - Ito, Shin

AU - Ito, Kenji

AU - Kawai, Shuichi

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AU - Nishi, Shohei

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AU - Shirane, Takeshi

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KW - Antimicrobial susceptibilities

KW - Japan

KW - Nationwide surveillance

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