Abstract
The novel DNA interactive quinoxaline-carbohydrate hybrids possessing disaccharides as the carbohydrate moieties were designed and synthesized, and their DNA photocleaving abilities were evaluated in order to examine the effect of the disaccharide structures. The configurations of the glycosidic bonds in the disaccharide strongly affected the DNA photocleaving ability, and two β-glycosidic bond linkages were very effective for the DNA photocleavage. Furthermore, the quinoxaline-disaccharide hybrids exhibited selective cytotoxicity against cancer cells with photoirradiation.
| Original language | English |
|---|---|
| Pages (from-to) | 2777-2779 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 14 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2004 Jun 7 |
Keywords
- Carbohydrate
- Cytotoxicity
- DNA photocleavage
- Oligosaccharide
- Quinoxaline
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Toshima, K., Ozawa, T., Kimura, T., & Matsumura, S. (2004). The significant effect of the carbohydrate structures on the DNA photocleavage of the quinoxaline-carbohydrate hybrids. Bioorganic and Medicinal Chemistry Letters, 14(11), 2777-2779. https://doi.org/10.1016/j.bmcl.2004.03.065