The specific opioid κ-agonist U-50,488H inhibits low Km GTPase

Hiroshi Ueda, Hidemi Misawa, Nobuyuki Fukushima, Hiroshi Takagi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

DAGO, a specific opioid μ-agonists stimulated the low Km GTPase activity of membranes of the guinea-pig striatum at 1-1000 nM and this effect was antagonized by naloxone 10-100 nM. On the other hand, U-50,488H, a specific opioid κ-agonist inhibited the low Km GTPase activity of membranes of the guinea-pig cerebellum at 1-100 nM. As this effect was antagonized by MR2266 but not by naloxone, the findings suggest that opioid μ- and κ-receptor stimulation is probably linked to the stimulation and inhibition of low Km GTPase, respectively.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalEuropean Journal of Pharmacology
Volume138
Issue number1
DOIs
Publication statusPublished - 1987 Jun 12
Externally publishedYes

Fingerprint

(trans)-Isomer 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide
GTP Phosphohydrolases
Opioid Analgesics
Naloxone
Guinea Pigs
Ala(2)-MePhe(4)-Gly(5)-enkephalin
Membranes
Opioid Receptors
Cerebellum

Keywords

  • GTPase (low Km)
  • Opioid κ-receptor
  • U-50,488H

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

The specific opioid κ-agonist U-50,488H inhibits low Km GTPase. / Ueda, Hiroshi; Misawa, Hidemi; Fukushima, Nobuyuki; Takagi, Hiroshi.

In: European Journal of Pharmacology, Vol. 138, No. 1, 12.06.1987, p. 129-132.

Research output: Contribution to journalArticle

Ueda, Hiroshi ; Misawa, Hidemi ; Fukushima, Nobuyuki ; Takagi, Hiroshi. / The specific opioid κ-agonist U-50,488H inhibits low Km GTPase. In: European Journal of Pharmacology. 1987 ; Vol. 138, No. 1. pp. 129-132.
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