The specific opioid κ-agonist U-50,488H inhibits low Km GTPase

Hiroshi Ueda, Hidemi Misawa, Nobuyuki Fukushima, Hiroshi Takagi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

DAGO, a specific opioid μ-agonists stimulated the low Km GTPase activity of membranes of the guinea-pig striatum at 1-1000 nM and this effect was antagonized by naloxone 10-100 nM. On the other hand, U-50,488H, a specific opioid κ-agonist inhibited the low Km GTPase activity of membranes of the guinea-pig cerebellum at 1-100 nM. As this effect was antagonized by MR2266 but not by naloxone, the findings suggest that opioid μ- and κ-receptor stimulation is probably linked to the stimulation and inhibition of low Km GTPase, respectively.

Original languageEnglish
Pages (from-to)129-132
Number of pages4
JournalEuropean journal of pharmacology
Volume138
Issue number1
DOIs
Publication statusPublished - 1987 Jun 12
Externally publishedYes

Keywords

  • GTPase (low Km)
  • Opioid κ-receptor
  • U-50,488H

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'The specific opioid κ-agonist U-50,488H inhibits low Km GTPase'. Together they form a unique fingerprint.

  • Cite this