The Sprouty/Spred family as tumor suppressors: Coming of age

Tetsuro Kawazoe, Koji Taniguchi

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

The Ras/Raf/ERK pathway is one of the most frequently dysregulated signaling pathways in various cancers. In some such cancers, Ras and Raf are hotspots for mutations, which cause continuous activation of this pathway. However, in some other cancers, it is known that negative regulators of the Ras/Raf/ERK pathway are responsible for uncontrolled activation. The Sprouty/Spred family is broadly recognized as important negative regulators of the Ras/Raf/ERK pathway, and its expression is downregulated in many malignancies, leading to hyperactivation of the Ras/Raf/ERK pathway. After the discovery of this family, intensive research investigated the mechanism by which it suppresses the Ras/Raf/ERK pathway and its roles in developmental and pathophysiological processes. In this review, we discuss the complicated roles of the Sprouty/Spred family in tumor initiation, promotion, and progression and its future therapeutic potential.

Original languageEnglish
Pages (from-to)1525-1535
Number of pages11
JournalCancer science
Volume110
Issue number5
DOIs
Publication statusPublished - 2019 May

Keywords

  • Ras/Raf/ERK
  • Sprouty/Spred
  • cancer
  • oncogene
  • tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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