The structures of citreohybridone A and B novel sesterterpenoid-type metabolites of a hybrid strain KO 0031 derived from penicillium citreo-viride B. IFO 6200 and 4692

Seiji Kosemura; Kimihiro Matsunaga; Shosuke Yamamura; Mari Kubota; Shigeru Ohba

doi:10.1016/0040-4039(91)80828-T

The structures of citreohybridone A and B novel sesterterpenoid-type metabolites of a hybrid strain KO 0031 derived from penicillium citreo-viride B. IFO 6200 and 4692

Seiji Kosemura, Kimihiro Matsunaga, Shosuke Yamamura, Mari Kubota, Shigeru Ohba

School of Medicine

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Two new cytotoxic substances against HeLa cell, citreohybridone A and B, have been isolated from the mycelium of a hybrid strain KO 0031 derived from Penicillium citreo-viride B.IFO 6200 and 4692, and their stereostructures have also been elucidated on the basis of their spectral data coupled with an X-ray crystallographic analysis of the citreohybridone A. These metabolites are regarded as new type of sesterterpenoids.

Original language	English
Pages (from-to)	3543-3546
Number of pages	4
Journal	Tetrahedron Letters
Volume	32
Issue number	29
DOIs	https://doi.org/10.1016/0040-4039(91)80828-T
Publication status	Published - 1991 Jul 15

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "The structures of citreohybridone A and B novel sesterterpenoid-type metabolites of a hybrid strain KO 0031 derived from penicillium citreo-viride B. IFO 6200 and 4692",

abstract = "Two new cytotoxic substances against HeLa cell, citreohybridone A and B, have been isolated from the mycelium of a hybrid strain KO 0031 derived from Penicillium citreo-viride B.IFO 6200 and 4692, and their stereostructures have also been elucidated on the basis of their spectral data coupled with an X-ray crystallographic analysis of the citreohybridone A. These metabolites are regarded as new type of sesterterpenoids.",

author = "Seiji Kosemura and Kimihiro Matsunaga and Shosuke Yamamura and Mari Kubota and Shigeru Ohba",

note = "Funding Information: The authorsw ish to thank the Ministry of Education, science and culture for financial support.T hey are also indebted to Miss. Fumiko Kobayashi (Research Laboratories, PharmaceuticalsG roup, Nippon Kayaku Co. Ltd.) for biologtcal tests.",

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doi = "10.1016/0040-4039(91)80828-T",

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T1 - The structures of citreohybridone A and B novel sesterterpenoid-type metabolites of a hybrid strain KO 0031 derived from penicillium citreo-viride B. IFO 6200 and 4692

AU - Kosemura, Seiji

AU - Matsunaga, Kimihiro

AU - Yamamura, Shosuke

AU - Kubota, Mari

AU - Ohba, Shigeru

N1 - Funding Information: The authorsw ish to thank the Ministry of Education, science and culture for financial support.T hey are also indebted to Miss. Fumiko Kobayashi (Research Laboratories, PharmaceuticalsG roup, Nippon Kayaku Co. Ltd.) for biologtcal tests.

PY - 1991/7/15

Y1 - 1991/7/15

N2 - Two new cytotoxic substances against HeLa cell, citreohybridone A and B, have been isolated from the mycelium of a hybrid strain KO 0031 derived from Penicillium citreo-viride B.IFO 6200 and 4692, and their stereostructures have also been elucidated on the basis of their spectral data coupled with an X-ray crystallographic analysis of the citreohybridone A. These metabolites are regarded as new type of sesterterpenoids.

AB - Two new cytotoxic substances against HeLa cell, citreohybridone A and B, have been isolated from the mycelium of a hybrid strain KO 0031 derived from Penicillium citreo-viride B.IFO 6200 and 4692, and their stereostructures have also been elucidated on the basis of their spectral data coupled with an X-ray crystallographic analysis of the citreohybridone A. These metabolites are regarded as new type of sesterterpenoids.

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The structures of citreohybridone A and B novel sesterterpenoid-type metabolites of a hybrid strain KO 0031 derived from penicillium citreo-viride B. IFO 6200 and 4692

Abstract

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