The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner

Toshiyuki Nakagawa, Hideyuki Okano, Teiichi Furuichi, Jun Aruga, Katsuhiko Mikoshiba

Research output: Contribution to journalArticlepeer-review

204 Citations (Scopus)

Abstract

Additional subtypes of the inositol 1,4,5-trisphosphate (InsP3) receptor are expressed in a tissue-specific and developmentally specific manner. They differ from the InsP3 receptor structure previously reported in two small variably spliced segments. One segment (SI) is located within the InsP3 binding site, whereas another segment (SII) is located near putative sites for phosphorylation and ATP binding to modulate InsP3 action on Ca2+ flux. Therefore, we speculate that selective use of InsP3 receptor subtypes permits a tissue-specific and developmentally specific expression of functionally distinct channels.

Original languageEnglish
Pages (from-to)6244-6248
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume88
Issue number14
DOIs
Publication statusPublished - 1991 Jul 15
Externally publishedYes

Keywords

  • Alternative splicing
  • Ligand-gated calcium channel

ASJC Scopus subject areas

  • General

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