The synthesis and biological activity of pyranonaphthoquione derivatives from Streptomyces sp. and their related substances

Akiko Shimbashi, Ayako Tsuchiya, Masaya Imoto, Shigeru Nishiyama

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6 Citations (Scopus)


The total synthesis of a novel pyranonaphthoquinone (2) having Cdc25A phosphatase inhibitory activity is achieved. The key step in this synthetic pathway is the intramolecular Michael addition for construction of the pyran ring system. The inhibitory activity of several derivatives, readily obtained from synthetic intermediates of 2, is assessed. The resulting data indicates that the pyran ring moiety is not a crucial factor for the activity.

Original languageEnglish
Pages (from-to)1925-1930
Number of pages6
JournalBulletin of the Chemical Society of Japan
Issue number10
Publication statusPublished - 2004 Oct 1


ASJC Scopus subject areas

  • Chemistry(all)

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