The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity

Yusuke Ichiyama, Shumpei Obata, Yoshitsugu Saishin, Osamu Sawada, Masashi Kakinoki, Tomoko Sawada, Yoshiaki Kubota, Masahito Ohji

Research output: Contribution to journalArticlepeer-review

Abstract

Retinopathy of prematurity (ROP) is a leading cause of childhood blindness and intravitreal anti-vascular endothelial growth factor (VEGF) injection is becoming a first-line choice for treatment of ROP. However, there is a major concern that intravitreally injected anti-VEGF agents could escape from the eye into the systemic circulation and impair systemic development. Moreover, escaped anti-VEGF agents could have an effect on the retina of the fellow eye. In this study, we investigated the hematogenous effect of a single intravitreal anti-VEGF injection in a mouse model of ROP. Here, we showed that single intravitreal aflibercept injection to one eye can affect body weight gain, the fellow eye, and renal vessels, although no apparent effect was observed in brain vessels. Furthermore, this hematogenous effect was dose-dependent. Our results provide very important insights into the clinical use of anti-VEGF agents for ROP treatment.

Original languageEnglish
Article numbere21390
JournalFASEB Journal
Volume35
Issue number3
DOIs
Publication statusPublished - 2021 Mar

Keywords

  • anti-vascular endothelial growth factor
  • fellow eye
  • hematogenous effect
  • retinopathy of prematurity
  • systemic effect

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity'. Together they form a unique fingerprint.

Cite this