Abstract
The first total synthesis of rifamycin W (1) has been accomplished by coupling two segments of the aliphatic ansa-chain 40 and the aromatic chromophore 12. The totally enantiospecific sequence elucidates the configurations of the C28 position and the C12 - C29 double bond to be R and E, respectively.
Original language | English |
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Pages (from-to) | 4629-4652 |
Number of pages | 24 |
Journal | Tetrahedron |
Volume | 46 |
Issue number | 13-14 |
DOIs | |
Publication status | Published - 1990 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry