The total synthesis of rifamycin W

Masaya Nakata, Nobutake Akiyama, Jun ichi Kamata, Kyoko Kojima, Hirokazu Masuda, Mitsuhiro Kinoshita, Kuniaki Tatsuta

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The first total synthesis of rifamycin W (1) has been accomplished by coupling two segments of the aliphatic ansa-chain 40 and the aromatic chromophore 12. The totally enantiospecific sequence elucidates the configurations of the C28 position and the C12 - C29 double bond to be R and E, respectively.

Original languageEnglish
Pages (from-to)4629-4652
Number of pages24
JournalTetrahedron
Volume46
Issue number13-14
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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