The total synthesis of rifamycin W

Masaya Nakata; Nobutake Akiyama; Jun ichi Kamata; Kyoko Kojima; Hirokazu Masuda; Mitsuhiro Kinoshita; Kuniaki Tatsuta

doi:10.1016/S0040-4020(01)85586-1

The total synthesis of rifamycin W

Masaya Nakata, Nobutake Akiyama, Jun ichi Kamata, Kyoko Kojima, Hirokazu Masuda, Mitsuhiro Kinoshita, Kuniaki Tatsuta

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

The first total synthesis of rifamycin W (1) has been accomplished by coupling two segments of the aliphatic ansa-chain 40 and the aromatic chromophore 12. The totally enantiospecific sequence elucidates the configurations of the C28 position and the C12 - C29 double bond to be R and E, respectively.

Original language	English
Pages (from-to)	4629-4652
Number of pages	24
Journal	Tetrahedron
Volume	46
Issue number	13-14
DOIs	https://doi.org/10.1016/S0040-4020(01)85586-1
Publication status	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "The total synthesis of rifamycin W",

abstract = "The first total synthesis of rifamycin W (1) has been accomplished by coupling two segments of the aliphatic ansa-chain 40 and the aromatic chromophore 12. The totally enantiospecific sequence elucidates the configurations of the C28 position and the C12 - C29 double bond to be R and E, respectively.",

author = "Masaya Nakata and Nobutake Akiyama and Kamata, {Jun ichi} and Kyoko Kojima and Hirokazu Masuda and Mitsuhiro Kinoshita and Kuniaki Tatsuta",

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AU - Nakata, Masaya

AU - Akiyama, Nobutake

AU - Kamata, Jun ichi

AU - Kojima, Kyoko

AU - Masuda, Hirokazu

AU - Kinoshita, Mitsuhiro

AU - Tatsuta, Kuniaki

PY - 1990

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