The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster

Yuki Hirota, Kazunobu Sawamoto, Kuniaki Takahashi, Ryu Ueda, Hideyuki Okano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalDevelopment Genes and Evolution
Volume215
Issue number2
DOIs
Publication statusPublished - 2005 Feb

Fingerprint

transmembrane proteins
compound eyes
Drosophila melanogaster
eyes
peripheral nervous system
Messenger RNA
protein
morphogenesis
Peripheral Nervous System
nervous system
RNA Interference
furrows
RNA interference
Morphogenesis
developmental stage
midgut
cell differentiation
Drosophila
central nervous system
Embryonic Development

Keywords

  • Differentiation
  • Drosophila melanogaster
  • Ommatidial cells
  • Tincar
  • Transmembrane protein

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster. / Hirota, Yuki; Sawamoto, Kazunobu; Takahashi, Kuniaki; Ueda, Ryu; Okano, Hideyuki.

In: Development Genes and Evolution, Vol. 215, No. 2, 02.2005, p. 90-96.

Research output: Contribution to journalArticle

@article{fa92c29ce8b64bac99ee1bdf43f829c0,
title = "The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster",
abstract = "We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.",
keywords = "Differentiation, Drosophila melanogaster, Ommatidial cells, Tincar, Transmembrane protein",
author = "Yuki Hirota and Kazunobu Sawamoto and Kuniaki Takahashi and Ryu Ueda and Hideyuki Okano",
year = "2005",
month = "2",
doi = "10.1007/s00427-004-0452-y",
language = "English",
volume = "215",
pages = "90--96",
journal = "Development Genes and Evolution",
issn = "0949-944X",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster

AU - Hirota, Yuki

AU - Sawamoto, Kazunobu

AU - Takahashi, Kuniaki

AU - Ueda, Ryu

AU - Okano, Hideyuki

PY - 2005/2

Y1 - 2005/2

N2 - We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.

AB - We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.

KW - Differentiation

KW - Drosophila melanogaster

KW - Ommatidial cells

KW - Tincar

KW - Transmembrane protein

UR - http://www.scopus.com/inward/record.url?scp=14544287457&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=14544287457&partnerID=8YFLogxK

U2 - 10.1007/s00427-004-0452-y

DO - 10.1007/s00427-004-0452-y

M3 - Article

C2 - 15654626

AN - SCOPUS:14544287457

VL - 215

SP - 90

EP - 96

JO - Development Genes and Evolution

JF - Development Genes and Evolution

SN - 0949-944X

IS - 2

ER -