Abstract
We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
| Original language | English |
|---|---|
| Pages (from-to) | 90-96 |
| Number of pages | 7 |
| Journal | Development Genes and Evolution |
| Volume | 215 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2005 Feb |
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Keywords
- Differentiation
- Drosophila melanogaster
- Ommatidial cells
- Tincar
- Transmembrane protein
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology
- Genetics
- Ecology, Evolution, Behavior and Systematics
Cite this
The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster. / Hirota, Yuki; Sawamoto, Kazunobu; Takahashi, Kuniaki; Ueda, Ryu; Okano, Hideyuki.
In: Development Genes and Evolution, Vol. 215, No. 2, 02.2005, p. 90-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster
AU - Hirota, Yuki
AU - Sawamoto, Kazunobu
AU - Takahashi, Kuniaki
AU - Ueda, Ryu
AU - Okano, Hideyuki
PY - 2005/2
Y1 - 2005/2
N2 - We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
AB - We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.
KW - Differentiation
KW - Drosophila melanogaster
KW - Ommatidial cells
KW - Tincar
KW - Transmembrane protein
UR - http://www.scopus.com/inward/record.url?scp=14544287457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=14544287457&partnerID=8YFLogxK
U2 - 10.1007/s00427-004-0452-y
DO - 10.1007/s00427-004-0452-y
M3 - Article
C2 - 15654626
AN - SCOPUS:14544287457
VL - 215
SP - 90
EP - 96
JO - Development Genes and Evolution
JF - Development Genes and Evolution
SN - 0949-944X
IS - 2
ER -