The transmembrane protein, Tincar, is involved in the development of the compound eye in Drosophila melanogaster

Yuki Hirota, Kazunobu Sawamoto, Kuniaki Takahashi, Ryu Ueda, Hideyuki Okano

Research output: Contribution to journalArticle

2 Citations (Scopus)


We previously cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions of tinc during developmental processes. Tinc mRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc, tinc mRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested that tinc may have an indispensable role in the normal differentiation of ommatidial cells.

Original languageEnglish
Pages (from-to)90-96
Number of pages7
JournalDevelopment Genes and Evolution
Issue number2
Publication statusPublished - 2005 Feb 1



  • Differentiation
  • Drosophila melanogaster
  • Ommatidial cells
  • Tincar
  • Transmembrane protein

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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