The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations

Koji Tsuta, Mitsumasa Kawago, Eisuke Inoue, Akihiko Yoshida, Fumiaki Takahashi, Hiroyuki Sakurai, Shun ichi Watanabe, Masahiro Takeuchi, Koh Furuta, Hisao Asamura, Hitoshi Tsuda

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Background: The present study aimed to determine the ability of the revised International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification of lung adenocarcinoma to predict patient survivals and driver gene alterations. Patients and Methods: A reclassification of 904 surgically resected adenocarcinomas was performed. The results were statistically analyzed to examine the correlation between the classification and overall survival (OS) using Cox regression analyses, and integrated discrimination improvement (IDI) analyses. Results: The 5-year OS rates for adenocarcinomas in situ (AIS) or minimally invasive adenocarcinoma (MIA) were 98%. Five-year OS rates of Lepidic-, acinar-, papillary-, micropapillary-, and solid-predominant adenocarcinomas was 93%, 67%, 74%, 62%, and 58%, respectively. The IDI estimates revealed that classification of ADC into the 7 subgroups had a higher estimated (0.0175) than did the combined histological grouping (AIS. +. MIA, lepidic. +. acinar. +. papillary, micropapillary. +. solid. +. others) (0.0111). Epidermal growth factor receptor mutations, KRAS gene mutations, and anaplastic lymphoma kinase gene alterations were statistically prevalent in papillary-predominant ( P= 0.00001), invasive mucinous ( P= 0.00001), and micropapillary- and acinar-predominant ( P= 0.00001) adenocarcinomas, respectively. Conclusions: The new classification reflects disease prognosis, and was also associated with driver gene alterations.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalLung Cancer
Volume81
Issue number3
DOIs
Publication statusPublished - 2013 Sep
Externally publishedYes

Fingerprint

Lung Neoplasms
Adenocarcinoma
Thorax
Genes
Survival Rate
Mutation
Survival
Epidermal Growth Factor Receptor
Regression Analysis
Adenocarcinoma of lung
Adenocarcinoma in Situ

Keywords

  • Adenocarcinoma of the lung
  • ALK
  • EGFR
  • IASLC classification
  • KRAS

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

Cite this

The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. / Tsuta, Koji; Kawago, Mitsumasa; Inoue, Eisuke; Yoshida, Akihiko; Takahashi, Fumiaki; Sakurai, Hiroyuki; Watanabe, Shun ichi; Takeuchi, Masahiro; Furuta, Koh; Asamura, Hisao; Tsuda, Hitoshi.

In: Lung Cancer, Vol. 81, No. 3, 09.2013, p. 371-376.

Research output: Contribution to journalArticle

Tsuta, K, Kawago, M, Inoue, E, Yoshida, A, Takahashi, F, Sakurai, H, Watanabe, SI, Takeuchi, M, Furuta, K, Asamura, H & Tsuda, H 2013, 'The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations', Lung Cancer, vol. 81, no. 3, pp. 371-376. https://doi.org/10.1016/j.lungcan.2013.06.012
Tsuta, Koji ; Kawago, Mitsumasa ; Inoue, Eisuke ; Yoshida, Akihiko ; Takahashi, Fumiaki ; Sakurai, Hiroyuki ; Watanabe, Shun ichi ; Takeuchi, Masahiro ; Furuta, Koh ; Asamura, Hisao ; Tsuda, Hitoshi. / The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations. In: Lung Cancer. 2013 ; Vol. 81, No. 3. pp. 371-376.
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AU - Kawago, Mitsumasa

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AU - Yoshida, Akihiko

AU - Takahashi, Fumiaki

AU - Sakurai, Hiroyuki

AU - Watanabe, Shun ichi

AU - Takeuchi, Masahiro

AU - Furuta, Koh

AU - Asamura, Hisao

AU - Tsuda, Hitoshi

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N2 - Background: The present study aimed to determine the ability of the revised International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification of lung adenocarcinoma to predict patient survivals and driver gene alterations. Patients and Methods: A reclassification of 904 surgically resected adenocarcinomas was performed. The results were statistically analyzed to examine the correlation between the classification and overall survival (OS) using Cox regression analyses, and integrated discrimination improvement (IDI) analyses. Results: The 5-year OS rates for adenocarcinomas in situ (AIS) or minimally invasive adenocarcinoma (MIA) were 98%. Five-year OS rates of Lepidic-, acinar-, papillary-, micropapillary-, and solid-predominant adenocarcinomas was 93%, 67%, 74%, 62%, and 58%, respectively. The IDI estimates revealed that classification of ADC into the 7 subgroups had a higher estimated (0.0175) than did the combined histological grouping (AIS. +. MIA, lepidic. +. acinar. +. papillary, micropapillary. +. solid. +. others) (0.0111). Epidermal growth factor receptor mutations, KRAS gene mutations, and anaplastic lymphoma kinase gene alterations were statistically prevalent in papillary-predominant ( P= 0.00001), invasive mucinous ( P= 0.00001), and micropapillary- and acinar-predominant ( P= 0.00001) adenocarcinomas, respectively. Conclusions: The new classification reflects disease prognosis, and was also associated with driver gene alterations.

AB - Background: The present study aimed to determine the ability of the revised International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification of lung adenocarcinoma to predict patient survivals and driver gene alterations. Patients and Methods: A reclassification of 904 surgically resected adenocarcinomas was performed. The results were statistically analyzed to examine the correlation between the classification and overall survival (OS) using Cox regression analyses, and integrated discrimination improvement (IDI) analyses. Results: The 5-year OS rates for adenocarcinomas in situ (AIS) or minimally invasive adenocarcinoma (MIA) were 98%. Five-year OS rates of Lepidic-, acinar-, papillary-, micropapillary-, and solid-predominant adenocarcinomas was 93%, 67%, 74%, 62%, and 58%, respectively. The IDI estimates revealed that classification of ADC into the 7 subgroups had a higher estimated (0.0175) than did the combined histological grouping (AIS. +. MIA, lepidic. +. acinar. +. papillary, micropapillary. +. solid. +. others) (0.0111). Epidermal growth factor receptor mutations, KRAS gene mutations, and anaplastic lymphoma kinase gene alterations were statistically prevalent in papillary-predominant ( P= 0.00001), invasive mucinous ( P= 0.00001), and micropapillary- and acinar-predominant ( P= 0.00001) adenocarcinomas, respectively. Conclusions: The new classification reflects disease prognosis, and was also associated with driver gene alterations.

KW - Adenocarcinoma of the lung

KW - ALK

KW - EGFR

KW - IASLC classification

KW - KRAS

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