Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue

Eiji Okada, Michael Firbank, Martin Schweiger, Simon R. Arridge, Mark Cope, David T. Delpy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

The effect of the layered surface tissues of the head on the measurement of brain oxygenation by near infrared spectroscopy (NIRS) has been investigated by both time-of-flight measurement and Monte Carlo simulation on models consisting of three or four separate layered homogeneous media. The clear cerebrospinal fluid (CSF) layer surrounding the brain has previously been shown to significantly affect light distribution, and in the head the brain surface is deeply folded with many CSF filled sulci. Therefore the most sophisticated model has four layers including a clear 'CSF' layer containing slots imitating sulci on the brain. Simpler models are also used and the light distributions in each are compared to examine the effect of the CSF layer. The mean optical pathlength of each model calculated from the temporal point spread function (TPSF) of the time-of-flight measurement agrees well with the Monte Carlo prediction. The fractional pathlength in each of the layers and the spatial sensitivity profile, which indicates the volume of tissue interrogated, are calculated by the Monte Carlo method. Results show that the light distribution in the head is highly affected by the existence of the clear CSF layer, and the optical pathlength and spatial sensitivity profile in the models with a clear layer are quite different from those without. However the presence of the sulci hardly affect the light distribution, the results from the sophisticated brain model with sulci being almost the same as those of the model with a simple CSF layer.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsBritton Chance, David T. Delpy, Gerhard J. Mueller
Pages2-8
Number of pages7
Volume2626
Publication statusPublished - 1995
Externally publishedYes
EventPhoton Propagation in Tissues - Barcelona, Spain
Duration: 1995 Sep 131995 Sep 14

Other

OtherPhoton Propagation in Tissues
CityBarcelona, Spain
Period95/9/1395/9/14

Fingerprint

Cerebrospinal fluid
Light propagation
cerebrospinal fluid
brain
Brain
Tissue
propagation
Brain models
Near infrared spectroscopy
Oxygenation
Optical transfer function
oxygenation
sensitivity
Monte Carlo methods
point spread functions
profiles
slots
Monte Carlo method
infrared spectroscopy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Okada, E., Firbank, M., Schweiger, M., Arridge, S. R., Cope, M., & Delpy, D. T. (1995). Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. In B. Chance, D. T. Delpy, & G. J. Mueller (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 2626, pp. 2-8)

Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. / Okada, Eiji; Firbank, Michael; Schweiger, Martin; Arridge, Simon R.; Cope, Mark; Delpy, David T.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / Britton Chance; David T. Delpy; Gerhard J. Mueller. Vol. 2626 1995. p. 2-8.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Okada, E, Firbank, M, Schweiger, M, Arridge, SR, Cope, M & Delpy, DT 1995, Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. in B Chance, DT Delpy & GJ Mueller (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 2626, pp. 2-8, Photon Propagation in Tissues, Barcelona, Spain, 95/9/13.
Okada E, Firbank M, Schweiger M, Arridge SR, Cope M, Delpy DT. Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. In Chance B, Delpy DT, Mueller GJ, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 2626. 1995. p. 2-8
Okada, Eiji ; Firbank, Michael ; Schweiger, Martin ; Arridge, Simon R. ; Cope, Mark ; Delpy, David T. / Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue. Proceedings of SPIE - The International Society for Optical Engineering. editor / Britton Chance ; David T. Delpy ; Gerhard J. Mueller. Vol. 2626 1995. pp. 2-8
@inproceedings{f25c2122e4b04da3a7c6d68779541c7f,
title = "Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue",
abstract = "The effect of the layered surface tissues of the head on the measurement of brain oxygenation by near infrared spectroscopy (NIRS) has been investigated by both time-of-flight measurement and Monte Carlo simulation on models consisting of three or four separate layered homogeneous media. The clear cerebrospinal fluid (CSF) layer surrounding the brain has previously been shown to significantly affect light distribution, and in the head the brain surface is deeply folded with many CSF filled sulci. Therefore the most sophisticated model has four layers including a clear 'CSF' layer containing slots imitating sulci on the brain. Simpler models are also used and the light distributions in each are compared to examine the effect of the CSF layer. The mean optical pathlength of each model calculated from the temporal point spread function (TPSF) of the time-of-flight measurement agrees well with the Monte Carlo prediction. The fractional pathlength in each of the layers and the spatial sensitivity profile, which indicates the volume of tissue interrogated, are calculated by the Monte Carlo method. Results show that the light distribution in the head is highly affected by the existence of the clear CSF layer, and the optical pathlength and spatial sensitivity profile in the models with a clear layer are quite different from those without. However the presence of the sulci hardly affect the light distribution, the results from the sophisticated brain model with sulci being almost the same as those of the model with a simple CSF layer.",
author = "Eiji Okada and Michael Firbank and Martin Schweiger and Arridge, {Simon R.} and Mark Cope and Delpy, {David T.}",
year = "1995",
language = "English",
isbn = "0819419907",
volume = "2626",
pages = "2--8",
editor = "Britton Chance and Delpy, {David T.} and Mueller, {Gerhard J.}",
booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

TY - GEN

T1 - Theoretical and experimental investigation of the effect of sulci on light propagation in brain tissue

AU - Okada, Eiji

AU - Firbank, Michael

AU - Schweiger, Martin

AU - Arridge, Simon R.

AU - Cope, Mark

AU - Delpy, David T.

PY - 1995

Y1 - 1995

N2 - The effect of the layered surface tissues of the head on the measurement of brain oxygenation by near infrared spectroscopy (NIRS) has been investigated by both time-of-flight measurement and Monte Carlo simulation on models consisting of three or four separate layered homogeneous media. The clear cerebrospinal fluid (CSF) layer surrounding the brain has previously been shown to significantly affect light distribution, and in the head the brain surface is deeply folded with many CSF filled sulci. Therefore the most sophisticated model has four layers including a clear 'CSF' layer containing slots imitating sulci on the brain. Simpler models are also used and the light distributions in each are compared to examine the effect of the CSF layer. The mean optical pathlength of each model calculated from the temporal point spread function (TPSF) of the time-of-flight measurement agrees well with the Monte Carlo prediction. The fractional pathlength in each of the layers and the spatial sensitivity profile, which indicates the volume of tissue interrogated, are calculated by the Monte Carlo method. Results show that the light distribution in the head is highly affected by the existence of the clear CSF layer, and the optical pathlength and spatial sensitivity profile in the models with a clear layer are quite different from those without. However the presence of the sulci hardly affect the light distribution, the results from the sophisticated brain model with sulci being almost the same as those of the model with a simple CSF layer.

AB - The effect of the layered surface tissues of the head on the measurement of brain oxygenation by near infrared spectroscopy (NIRS) has been investigated by both time-of-flight measurement and Monte Carlo simulation on models consisting of three or four separate layered homogeneous media. The clear cerebrospinal fluid (CSF) layer surrounding the brain has previously been shown to significantly affect light distribution, and in the head the brain surface is deeply folded with many CSF filled sulci. Therefore the most sophisticated model has four layers including a clear 'CSF' layer containing slots imitating sulci on the brain. Simpler models are also used and the light distributions in each are compared to examine the effect of the CSF layer. The mean optical pathlength of each model calculated from the temporal point spread function (TPSF) of the time-of-flight measurement agrees well with the Monte Carlo prediction. The fractional pathlength in each of the layers and the spatial sensitivity profile, which indicates the volume of tissue interrogated, are calculated by the Monte Carlo method. Results show that the light distribution in the head is highly affected by the existence of the clear CSF layer, and the optical pathlength and spatial sensitivity profile in the models with a clear layer are quite different from those without. However the presence of the sulci hardly affect the light distribution, the results from the sophisticated brain model with sulci being almost the same as those of the model with a simple CSF layer.

UR - http://www.scopus.com/inward/record.url?scp=0029491157&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029491157&partnerID=8YFLogxK

M3 - Conference contribution

SN - 0819419907

SN - 9780819419903

VL - 2626

SP - 2

EP - 8

BT - Proceedings of SPIE - The International Society for Optical Engineering

A2 - Chance, Britton

A2 - Delpy, David T.

A2 - Mueller, Gerhard J.

ER -