Theranostic system for drug delivery and pharmacokinetic imaging based on nanosecond pulsed light-induced photomechanical and photoacoustic effects

Yasuyuki Tsunoi, Shunichi Sato, Satoko Kawauchi, Yusuke Akutsu, Yoshihiro Miyagawa, Koji Araki, Akihiro Shiotani, Mitsuhiro Terakawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

For efficient and side effects-free pharmacological treatment, we here propose a theranostic system that enables transvascular drug delivery by photomechanical waves (PMWs) and photoacoustic (PA) imaging of the drug distribution; both functions are based on nanosecond laser pulses and can therefore be integrated in one system. Through optical fibers arranged around an ultrasound sensor, low-energy and high-energy nanosecond light pulses were transmitted respectively for PA imaging and PMW-based drug delivery by temporal switching. With the system, we delivered a test drug (Evans blue) to tumors in mice and visualized distributions of both the blood vessels and drug in the tissue in vivo, showing the validity of the system.

Original languageEnglish
Article number116601
JournalJapanese Journal of Applied Physics
Volume54
Issue number11
DOIs
Publication statusPublished - 2015 Nov 1

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photomechanical effect
Pharmacokinetics
Photoacoustic effect
Drug delivery
delivery
drugs
Imaging techniques
Blood vessels
Optical fibers
Tumors
Laser pulses
Ultrasonics
Tissue
Sensors
blood vessels
pulses
mice
tumors
optical fibers
energy

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

Theranostic system for drug delivery and pharmacokinetic imaging based on nanosecond pulsed light-induced photomechanical and photoacoustic effects. / Tsunoi, Yasuyuki; Sato, Shunichi; Kawauchi, Satoko; Akutsu, Yusuke; Miyagawa, Yoshihiro; Araki, Koji; Shiotani, Akihiro; Terakawa, Mitsuhiro.

In: Japanese Journal of Applied Physics, Vol. 54, No. 11, 116601, 01.11.2015.

Research output: Contribution to journalArticle

Tsunoi, Yasuyuki ; Sato, Shunichi ; Kawauchi, Satoko ; Akutsu, Yusuke ; Miyagawa, Yoshihiro ; Araki, Koji ; Shiotani, Akihiro ; Terakawa, Mitsuhiro. / Theranostic system for drug delivery and pharmacokinetic imaging based on nanosecond pulsed light-induced photomechanical and photoacoustic effects. In: Japanese Journal of Applied Physics. 2015 ; Vol. 54, No. 11.
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AU - Miyagawa, Yoshihiro

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