Theranostic system for drug delivery and pharmacokinetic imaging based on nanosecond pulsed light-induced photomechanical and photoacoustic effects

Yasuyuki Tsunoi, Shunichi Sato, Satoko Kawauchi, Yusuke Akutsu, Yoshihiro Miyagawa, Koji Araki, Akihiro Shiotani, Mitsuhiro Terakawa

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    For efficient and side effects-free pharmacological treatment, we here propose a theranostic system that enables transvascular drug delivery by photomechanical waves (PMWs) and photoacoustic (PA) imaging of the drug distribution; both functions are based on nanosecond laser pulses and can therefore be integrated in one system. Through optical fibers arranged around an ultrasound sensor, low-energy and high-energy nanosecond light pulses were transmitted respectively for PA imaging and PMW-based drug delivery by temporal switching. With the system, we delivered a test drug (Evans blue) to tumors in mice and visualized distributions of both the blood vessels and drug in the tissue in vivo, showing the validity of the system.

    Original languageEnglish
    Article number116601
    JournalJapanese Journal of Applied Physics
    Volume54
    Issue number11
    DOIs
    Publication statusPublished - 2015 Nov 1

    ASJC Scopus subject areas

    • Engineering(all)
    • Physics and Astronomy(all)

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