Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel, S. Okamoto, S. Danhauser-Riedl, C. I. Hong, E. F. Winton, C. R. West, J. Rastetter, W. R. Vogler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalExperimental Hematology
Volume17
Issue number4
Publication statusPublished - 1989 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Genetics
  • Cell Biology
  • Cancer Research

Fingerprint Dive into the research topics of 'Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice'. Together they form a unique fingerprint.

  • Cite this

    Berdel, W. E., Okamoto, S., Danhauser-Riedl, S., Hong, C. I., Winton, E. F., West, C. R., Rastetter, J., & Vogler, W. R. (1989). Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice. Experimental Hematology, 17(4), 364-367.