Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel, Shinichiro Okamoto, S. Danhauser-Riedl, C. I. Hong, E. F. Winton, C. R. West, J. Rastetter, W. R. Vogler

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalExperimental Hematology
Volume17
Issue number4
Publication statusPublished - 1989
Externally publishedYes

Fingerprint

Cytidine Diphosphate
Cytarabine
Leukemia
Lipids
Transplantation
Sulfides
Esters
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Berdel, W. E., Okamoto, S., Danhauser-Riedl, S., Hong, C. I., Winton, E. F., West, C. R., ... Vogler, W. R. (1989). Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice. Experimental Hematology, 17(4), 364-367.

Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice. / Berdel, W. E.; Okamoto, Shinichiro; Danhauser-Riedl, S.; Hong, C. I.; Winton, E. F.; West, C. R.; Rastetter, J.; Vogler, W. R.

In: Experimental Hematology, Vol. 17, No. 4, 1989, p. 364-367.

Research output: Contribution to journalArticle

Berdel, WE, Okamoto, S, Danhauser-Riedl, S, Hong, CI, Winton, EF, West, CR, Rastetter, J & Vogler, WR 1989, 'Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice', Experimental Hematology, vol. 17, no. 4, pp. 364-367.
Berdel, W. E. ; Okamoto, Shinichiro ; Danhauser-Riedl, S. ; Hong, C. I. ; Winton, E. F. ; West, C. R. ; Rastetter, J. ; Vogler, W. R. / Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice. In: Experimental Hematology. 1989 ; Vol. 17, No. 4. pp. 364-367.
@article{a09ce64f20fa4456acd6653e3c952761,
title = "Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice",
abstract = "Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.",
author = "Berdel, {W. E.} and Shinichiro Okamoto and S. Danhauser-Riedl and Hong, {C. I.} and Winton, {E. F.} and West, {C. R.} and J. Rastetter and Vogler, {W. R.}",
year = "1989",
language = "English",
volume = "17",
pages = "364--367",
journal = "Experimental Hematology",
issn = "0301-472X",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

AU - Berdel, W. E.

AU - Okamoto, Shinichiro

AU - Danhauser-Riedl, S.

AU - Hong, C. I.

AU - Winton, E. F.

AU - West, C. R.

AU - Rastetter, J.

AU - Vogler, W. R.

PY - 1989

Y1 - 1989

N2 - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

AB - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

UR - http://www.scopus.com/inward/record.url?scp=0024559503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024559503&partnerID=8YFLogxK

M3 - Article

VL - 17

SP - 364

EP - 367

JO - Experimental Hematology

JF - Experimental Hematology

SN - 0301-472X

IS - 4

ER -