Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel; S. Okamoto; S. Danhauser-Riedl; C. I. Hong; E. F. Winton; C. R. West; J. Rastetter; W. R. Vogler

Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

W. E. Berdel, S. Okamoto, S. Danhauser-Riedl, C. I. Hong, E. F. Winton, C. R. West, J. Rastetter, W. R. Vogler

Research output: Contribution to journal › Article › peer-review

Abstract

Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

Original language	English
Pages (from-to)	364-367
Number of pages	4
Journal	Experimental Hematology
Volume	17
Issue number	4
Publication status	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Hematology
Genetics
Cell Biology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice",

abstract = "Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.",

author = "Berdel, {W. E.} and S. Okamoto and S. Danhauser-Riedl and Hong, {C. I.} and Winton, {E. F.} and West, {C. R.} and J. Rastetter and Vogler, {W. R.}",

year = "1989",

language = "English",

volume = "17",

pages = "364--367",

journal = "Experimental Hematology",

issn = "0301-472X",

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T1 - Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

AU - Berdel, W. E.

AU - Okamoto, S.

AU - Danhauser-Riedl, S.

AU - Hong, C. I.

AU - Winton, E. F.

AU - West, C. R.

AU - Rastetter, J.

AU - Vogler, W. R.

PY - 1989

Y1 - 1989

N2 - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

AB - Two new conjugates of 1-β-arabinofuranosylcytosine (ara-C) and lipids were tested for therapeutic activity in myelomonocytic WEHI-3B leukemia in mice. Both conjugates were superior to equimolar mixtures of their respective parent compounds and to ara-C alone. IP treatment was found effective after either IP or IV transplantation of the leukemia. The thioether-linked lipid conjugate ara-CDP-D,L-PTBA showed considerably higher efficacy than the ester-linked lipid conjugate ara-CDP-L-dipalmitin. The optimal therapeutic regimen of ara-CDP-D,L-PTBA consisted of 60 mg/kg given IP qd 1-5 after transplantation of the WEHI-3B leukemia.

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SN - 0301-472X

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JO - Experimental Hematology

JF - Experimental Hematology

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Therapeutic activity of 1-β-D-arabinofuranosylcytosine conjugates of lipids in WEHI-3B leukemia in mice

Abstract

ASJC Scopus subject areas

UN SDGs

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